Astrocytic pyruvate carboxylation: Status after 35 years
Research output: Contribution to journal › Review › Research › peer-review
Documents
- Schousboe_et_al-2019-Journal_of_Neuroscience_Research
Final published version, 739 KB, PDF document
The first two publications dealing with the question of the cellular localization of the enzyme pyruvate carboxylase (PC) which in the brain represents the most important metabolic pathway to allow anaplerosis of TCA cycle constituents were published in 1983 and 1985. Hence, 2018 marks the 35th anniversary of the notion based on the results of the publications provided above that PC-catalyzed anaplerosis in the brain is an astrocytic process. This review will provide the background for investigating this enzymatic pathway as well as a discussion of cataplerosis, the degradation of products from anaplerosis, and the current status of the functional significance of pyruvate carboxylation in brain metabolism.
Original language | English |
---|---|
Journal | Journal of Neuroscience Research |
Volume | 97 |
Pages (from-to) | 890-896 |
ISSN | 0360-4012 |
DOIs | |
Publication status | Published - 1 Jan 2019 |
- anaplerosis, astrocytes, cataplerosis, glutamate, glutamine, neurons
Research areas
Number of downloads are based on statistics from Google Scholar and www.ku.dk
ID: 222390875