A multisystem composite biomarker as a preliminary diagnostic test in bipolar disorder
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A multisystem composite biomarker as a preliminary diagnostic test in bipolar disorder. / Munkholm, K.; Vinberg, M.; Pedersen, B. K.; Poulsen, H. E.; Ekstrøm, C. T.; Kessing, L. V.
In: Acta Psychiatrica Scandinavica, Vol. 139, No. 3, 2019, p. 227-236.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - A multisystem composite biomarker as a preliminary diagnostic test in bipolar disorder
AU - Munkholm, K.
AU - Vinberg, M.
AU - Pedersen, B. K.
AU - Poulsen, H. E.
AU - Ekstrøm, C. T.
AU - Kessing, L. V.
PY - 2019
Y1 - 2019
N2 - Objective: Diagnosis and management of bipolar disorder (BD) are limited by the absence of available laboratory tests. We aimed to combine data from different molecular levels and tissues into a composite diagnostic and state biomarker. Methods: Expression levels of 19 candidate genes in peripheral blood, plasma levels of BDNF, NT-3, IL-6 and IL-18, leukocyte counts, and urinary markers of oxidative damage to DNA and RNA were measured in 37 adult rapid-cycling patients with BD in different affective states during a 6- to 12-month period and in 40 age- and gender-matched healthy individuals in a longitudinal, repeated measures design comprising a total of 211 samples. A composite biomarker was constructed using data-driven variable selection. Results: The composite biomarker discriminated between patients with BD and healthy control individuals with an area under the receiver operating characteristic curve (AUC) of 0.83 and a sensitivity of 73% and specificity of 71% corresponding with a moderately accurate test. Discrimination between manic and depressive states had a moderate accuracy, with an AUC of 0.82 and a sensitivity of 92% and a specificity of 40%. Conclusion: Combining individual biomarkers across tissues and molecular systems could be a promising avenue for research in biomarker models in BD.
AB - Objective: Diagnosis and management of bipolar disorder (BD) are limited by the absence of available laboratory tests. We aimed to combine data from different molecular levels and tissues into a composite diagnostic and state biomarker. Methods: Expression levels of 19 candidate genes in peripheral blood, plasma levels of BDNF, NT-3, IL-6 and IL-18, leukocyte counts, and urinary markers of oxidative damage to DNA and RNA were measured in 37 adult rapid-cycling patients with BD in different affective states during a 6- to 12-month period and in 40 age- and gender-matched healthy individuals in a longitudinal, repeated measures design comprising a total of 211 samples. A composite biomarker was constructed using data-driven variable selection. Results: The composite biomarker discriminated between patients with BD and healthy control individuals with an area under the receiver operating characteristic curve (AUC) of 0.83 and a sensitivity of 73% and specificity of 71% corresponding with a moderately accurate test. Discrimination between manic and depressive states had a moderate accuracy, with an AUC of 0.82 and a sensitivity of 92% and a specificity of 40%. Conclusion: Combining individual biomarkers across tissues and molecular systems could be a promising avenue for research in biomarker models in BD.
KW - biomarkers
KW - bipolar disorder
KW - blood
KW - gene expression
KW - urine
U2 - 10.1111/acps.12983
DO - 10.1111/acps.12983
M3 - Journal article
C2 - 30383306
AN - SCOPUS:85057553079
VL - 139
SP - 227
EP - 236
JO - Acta Psychiatrica Scandinavica
JF - Acta Psychiatrica Scandinavica
SN - 0001-690X
IS - 3
ER -
ID: 210293248