Urinary 1-hydroxypyrene, a PAH biomarker in foundry workers
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Urinary 1-hydroxypyrene, a PAH biomarker in foundry workers. / Omland, Øyvind; Sherson, D; Hansen, Åse Marie; Sigsgaard, Torben; Autrup, H; Overgaard, E.
I: Cancer Detection and Prevention, Bind 20, Nr. 1, 1996, s. 57-62.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Urinary 1-hydroxypyrene, a PAH biomarker in foundry workers
AU - Omland, Øyvind
AU - Sherson, D
AU - Hansen, Åse Marie
AU - Sigsgaard, Torben
AU - Autrup, H
AU - Overgaard, E
PY - 1996
Y1 - 1996
N2 - Exposure to PAH in foundry workers has been studied by urinary 1-hydroxypyrene (HPU) levels, quantitatively measured by reversed phase HPLC. Seventy male foundry workers and 68 matched controls were investigated. Polycyclic aromatic hydrocarbon (PAH) exposure was defined by 17 breathing zone hygienic samples, consisting of 16 selected PAH compounds. Mean total PAH concentration (SD) was 10.40 (4.04) mu g/m3. A multiple regression model of tobacco consumption, age, airborne PAH-exposure and foundry work on log HPU showed a significant correlation, p <0.001, r2 = 0.69. Only foundry work (p <0.0001) and airborne PAH exposure (p = 0.0478) contributed significantly to the model. These data suggest that HPU is a sensitive biomarker for low-dose PAH exposure.
AB - Exposure to PAH in foundry workers has been studied by urinary 1-hydroxypyrene (HPU) levels, quantitatively measured by reversed phase HPLC. Seventy male foundry workers and 68 matched controls were investigated. Polycyclic aromatic hydrocarbon (PAH) exposure was defined by 17 breathing zone hygienic samples, consisting of 16 selected PAH compounds. Mean total PAH concentration (SD) was 10.40 (4.04) mu g/m3. A multiple regression model of tobacco consumption, age, airborne PAH-exposure and foundry work on log HPU showed a significant correlation, p <0.001, r2 = 0.69. Only foundry work (p <0.0001) and airborne PAH exposure (p = 0.0478) contributed significantly to the model. These data suggest that HPU is a sensitive biomarker for low-dose PAH exposure.
KW - Adult
KW - Aged
KW - Air Pollutants, Occupational
KW - Biological Markers
KW - Chromatography, High Pressure Liquid
KW - Humans
KW - Industry
KW - Male
KW - Middle Aged
KW - Mutagens
KW - Occupational Exposure
KW - Polycyclic Hydrocarbons, Aromatic
KW - Pyrenes
M3 - Journal article
C2 - 8907204
VL - 20
SP - 57
EP - 62
JO - Cancer Detection and Prevention
JF - Cancer Detection and Prevention
SN - 0361-090X
IS - 1
ER -
ID: 48865756