Systematic review on the current knowledge and use of single-cell RNA sequencing in head and neck cancer
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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Single-cell RNA sequencing (scRNA-seq) is a novel method enabling genetic characterization of tumor tissue at a single-cell level. This study systematically reviewed the literature on studies using scRNA-seq to characterize head and neck squamous cell carcinomas (HNSCCs). Seven studies were included, of which two studies performed scRNA-seq on 20 patients in total, and five studies used scRNA-seq data in a subsequent clinical study. The former mentioned two studies found intra-tumoral genetic heterogeneity among malignant cells but genetic uniformity among non-malignant cells. The five latter studies used scRNA-seq data in various ways. Three studies identified biomarkers related to predicting whether a patient would benefit from immunotherapeutic treatment. One study characterized genes related to the perineural invasion. One study identified genes to be used in diagnostics. Further studies performing scRNA-seq on HNSCC are required to continue the ongoing development and use of scRNA-seq.
Originalsprog | Engelsk |
---|---|
Tidsskrift | APMIS |
Vol/bind | 129 |
Udgave nummer | 11 |
Sider (fra-til) | 619-625 |
Antal sider | 7 |
ISSN | 0903-4641 |
DOI | |
Status | Udgivet - 2021 |
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Publisher Copyright:
© 2021 Scandinavian Societies for Medical Microbiology and Pathology
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