Participation bias in a randomised trial of screening for lung cancer
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Participation bias in a randomised trial of screening for lung cancer. / Hestbech, Mie Sara; Siersma, Volkert; Dirksen, Asger; Pedersen, Jesper H; Brodersen, John.
I: Lung Cancer, Bind 73, Nr. 3, 2011, s. 325-31.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Participation bias in a randomised trial of screening for lung cancer
AU - Hestbech, Mie Sara
AU - Siersma, Volkert
AU - Dirksen, Asger
AU - Pedersen, Jesper H
AU - Brodersen, John
N1 - Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.
PY - 2011
Y1 - 2011
N2 - INTRODUCTION: Participation bias might affect the results and the representability of randomised controlled trials. We investigated the degree of socio-demographic and psychosocial participation bias in the Danish Lung Cancer Screening Trial (DLCST). METHODS: In DLCST the questionnaire COS-LC (Consequences of Screening in Lung Cancer) was used to measure the psychosocial aspects of screening. To investigate a difference with a comparable representative sample from the Danish population, we sent out an inclusion questionnaire to 3999 Danes in the age from 50 to 70 years randomly selected from the Central National Register. Those who completed the inclusion questionnaire and met the inclusion criteria from DLCST received the COS-LC. Those who completed the COS-LC-and thus formed a population sample comparable to DLCST - were compared to the DLCST participants on socio-demographics and psychosocial measures. RESULTS: Participation rates were high among the comparable population sample: 75.3% completed the inclusion questionnaire and 77.4% of those who were eligible completed the COS-LC. The analyses revealed differences between the DLCST participants and the comparable population sample in the following socio-demographic aspects: social group, living alone, gender, age and geographical area. DLCST participants reported less negative psychosocial aspects than the comparable population sample. CONCLUSION: The present study has shown substantial socio-demographic and psychosocial participation bias in DLCST.
AB - INTRODUCTION: Participation bias might affect the results and the representability of randomised controlled trials. We investigated the degree of socio-demographic and psychosocial participation bias in the Danish Lung Cancer Screening Trial (DLCST). METHODS: In DLCST the questionnaire COS-LC (Consequences of Screening in Lung Cancer) was used to measure the psychosocial aspects of screening. To investigate a difference with a comparable representative sample from the Danish population, we sent out an inclusion questionnaire to 3999 Danes in the age from 50 to 70 years randomly selected from the Central National Register. Those who completed the inclusion questionnaire and met the inclusion criteria from DLCST received the COS-LC. Those who completed the COS-LC-and thus formed a population sample comparable to DLCST - were compared to the DLCST participants on socio-demographics and psychosocial measures. RESULTS: Participation rates were high among the comparable population sample: 75.3% completed the inclusion questionnaire and 77.4% of those who were eligible completed the COS-LC. The analyses revealed differences between the DLCST participants and the comparable population sample in the following socio-demographic aspects: social group, living alone, gender, age and geographical area. DLCST participants reported less negative psychosocial aspects than the comparable population sample. CONCLUSION: The present study has shown substantial socio-demographic and psychosocial participation bias in DLCST.
U2 - 10.1016/j.lungcan.2010.12.018
DO - 10.1016/j.lungcan.2010.12.018
M3 - Journal article
C2 - 21324544
VL - 73
SP - 325
EP - 331
JO - Lung Cancer
JF - Lung Cancer
SN - 0169-5002
IS - 3
ER -
ID: 33206003