Early-life environment influencing susceptibility to cytomegalovirus infection: evidence from the Leiden Longevity Study and the Longitudinal Study of Aging Danish Twins
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Early-life environment influencing susceptibility to cytomegalovirus infection : evidence from the Leiden Longevity Study and the Longitudinal Study of Aging Danish Twins. / Mortensen, Laust Hvas; Maier, A B; Slagbom, P E; Pawelec, G; Derhovanessian, E; Petersen, I.; Jahn, G; Westendorp, R G J; Christensen, K.
I: Epidemiology and Infection, Bind 140, Nr. 5, 2012, s. 835-841.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Early-life environment influencing susceptibility to cytomegalovirus infection
T2 - evidence from the Leiden Longevity Study and the Longitudinal Study of Aging Danish Twins
AU - Mortensen, Laust Hvas
AU - Maier, A B
AU - Slagbom, P E
AU - Pawelec, G
AU - Derhovanessian, E
AU - Petersen, I.
AU - Jahn, G
AU - Westendorp, R G J
AU - Christensen, K
PY - 2012
Y1 - 2012
N2 - Human cytomegalovirus (CMV) is a common herpesvirus establishing lifelong persisting infection, which has been implicated in immunosenescence and mortality in the elderly. Little is known about how and when susceptibility to CMV infection is determined. We measured CMV seroprevalence in two genetically informative cohorts. From the Leiden Longevity Study (LLS) we selected long-lived sib-pairs (n=844) and their middle-aged offspring and the offspring's partners (n=1452). From the Longitudinal Study of Aging Danish Twins (LSADT) 604 (302 pairs) same-sex monozygotic (MZ) and dizygotic (DZ) twins aged 73-94 years were included (n=302 pairs). Offspring of the long-lived LLS participants had significantly lower seroprevalence of CMV compared to their partners (offspring: 42% vs. partners: 51%, P=0·003). Of 372 offspring living with a CMV-positive partner, only 58% were infected. The corresponding number for partners was 71% (P<0·001). In the LSADT, MZ and DZ twins had high and similar CMV-positive concordance rates (MZ: 90% vs. DZ: 88%, P=0·51) suggesting that shared family environment accounts for the similarity within twin pairs. Our findings suggest that susceptibility to CMV infection--even under continuous within-partnership exposure--appears to be more strongly influenced by early-life environment than by genetic factors and adult environment.
AB - Human cytomegalovirus (CMV) is a common herpesvirus establishing lifelong persisting infection, which has been implicated in immunosenescence and mortality in the elderly. Little is known about how and when susceptibility to CMV infection is determined. We measured CMV seroprevalence in two genetically informative cohorts. From the Leiden Longevity Study (LLS) we selected long-lived sib-pairs (n=844) and their middle-aged offspring and the offspring's partners (n=1452). From the Longitudinal Study of Aging Danish Twins (LSADT) 604 (302 pairs) same-sex monozygotic (MZ) and dizygotic (DZ) twins aged 73-94 years were included (n=302 pairs). Offspring of the long-lived LLS participants had significantly lower seroprevalence of CMV compared to their partners (offspring: 42% vs. partners: 51%, P=0·003). Of 372 offspring living with a CMV-positive partner, only 58% were infected. The corresponding number for partners was 71% (P<0·001). In the LSADT, MZ and DZ twins had high and similar CMV-positive concordance rates (MZ: 90% vs. DZ: 88%, P=0·51) suggesting that shared family environment accounts for the similarity within twin pairs. Our findings suggest that susceptibility to CMV infection--even under continuous within-partnership exposure--appears to be more strongly influenced by early-life environment than by genetic factors and adult environment.
KW - Aged
KW - Aged, 80 and over
KW - Cytomegalovirus Infections
KW - Denmark
KW - Disease Susceptibility
KW - Female
KW - Humans
KW - Longevity
KW - Longitudinal Studies
KW - Male
KW - Netherlands
KW - Seroepidemiologic Studies
KW - Survival Analysis
KW - Twins
U2 - 10.1017/S0950268811001397
DO - 10.1017/S0950268811001397
M3 - Journal article
C2 - 21781370
VL - 140
SP - 835
EP - 841
JO - Epidemiology and Infection
JF - Epidemiology and Infection
SN - 0950-2688
IS - 5
ER -
ID: 137668910