Solid-phase polyamine synthesis using piperazine and piperidine building blocks

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Christian A Olsen, Matthias Witt, Jerzy W Jaroszewski, Henrik Franzyk

[reaction: see text]. Polyamines containing piperidine and piperazine moieties have been synthesized on solid support using SN2 alkylation of resin-bound secondary amines with 2-nitrobenzenesulfonates (nosylates). The effect of solvent on this alkylation was investigated. The methodology was employed for the total synthesis of novel analogues of wasp polyamine toxins (philanthotoxins).
OriginalsprogEngelsk
TidsskriftOrganic Letters
Vol/bind5
Udgave nummer22
Sider (fra-til)4183-5
Antal sider3
ISSN1523-7060
DOI
StatusUdgivet - 2003

ID: 42385442