Find en forsker – Københavns Universitet

A novel pseudo-complementary PNA G-C base pair

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Anne G. Olsen, Otto Dahl, Asger Bjørn Petersen, John Nielsen, Peter E. Nielsen

Pseudo-complementary oligonucleotide analogues and mimics provide novel opportunities for targeting duplex structures in RNA and DNA. Previously, a pseudo-complementary A-T base pair has been introduced. Towards sequence unrestricted targeting, a pseudo-complementary G-C base pair consisting of the unnatural nucleobases n6-methoxy-2,6-diaminopurine (previously described in a DNA context) and N4-benzoylcytosine is now presented for design of pseudo-complementary PNA oligomers (pcPNAs).
OriginalsprogEngelsk
TidsskriftArtificial DNA
Vol/bind2
Tidsskriftsnummer1
Sider (fra-til)33-37
Antal sider5
ISSN1949-095X
DOI
StatusUdgivet - 2011

ID: 33698499