Protein-Protein Interaction Databases

Publikation: Bidrag til bog/antologi/rapportBidrag til bog/antologiForskningfagfællebedømt

Damian Szklarczyk, Lars Juhl Jensen

Years of meticulous curation of scientific literature and increasingly reliable computational predictions have resulted in creation of vast databases of protein interaction data. Over the years, these repositories have become a basic framework in which experiments are analyzed and new directions of research are explored. Here we present an overview of the most widely used protein-protein interaction databases and the methods they employ to gather, combine, and predict interactions. We also point out the trade-off between comprehensiveness and accuracy and the main pitfall scientists have to be aware before adopting protein interaction databases in any single-gene or genome-wide analysis.

OriginalsprogEngelsk
TitelProtein-Protein Interactions : Methods and Applications
RedaktørerCheryl L. Meyerkord, Haian Fu
Antal sider18
Vol/bind1278
Udgivelses stedNew York
ForlagSpringer Publishing Company
Publikationsdato2015
Udgave2
Sider39-56
Kapitel3
ISBN (Trykt)978-1-4939-2424-0
ISBN (Elektronisk)978-1-4939-2425-7
DOI
StatusUdgivet - 2015
NavnMethods in Molecular Biology
Vol/bind1278
ISSN1064-3745

ID: 141012425