Assessment of disease activity in large-vessel vasculitis: Results of an international delphi exercise

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Sibel Z. Aydin, Haner Direskeneli, Peter A. Merkel, International Delphi on Disease Activity Assessment in Large-vessel Vasculitis, Sergio Toloza, Daniel Blockmans, Emilia Inoue Sato, Bo Baslund, Kenneth Warrington, Yusuf Yazici, Steven Ytterberg

Objective. To arrive at consensus for candidate outcomes for disease activity assessment in largevessel vasculitis (LVV) in clinical trials. Methods.A Delphi survey including 99 items was circulated among international experts for 3 rounds. Results. Fifty-seven items were accepted for both giant cell arteritis and Takayasu arteritis. Sixty-seven percent of experts voted to have a common approach for both diseases with additional disease-specific items such as weight loss, scalp tenderness/necrosis, morning stiffness, dizziness, visual symptoms, and imaging. Conclusion. This study highlights similarities and differences in experts' perspectives for assessing clinical activity in LVV and may guide a consensus-driven core set of validated outcomes.

OriginalsprogEngelsk
TidsskriftJournal of Rheumatology
Vol/bind44
Udgave nummer12
Sider (fra-til)1928-1932
Antal sider5
ISSN0315-162X
DOI
StatusUdgivet - dec. 2017

ID: 188268784