Soluble Interleukin-7 receptor levels and risk of acute graft-versus-disease after allogeneic haematopoietic stem cell transplantation

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Katrine Kielsen, Zaiba Shamim, Stephanie Thiant, Sylvie Faucher, Wendy Decker, Ib Jarle Christensen, Lars Peter Ryder, Ibrahim Yakoub-Agha, Klaus Müller

Interleukin-7 is a cytokine essential for T cell homeostasis. IL-7 binds to cellular IL-7 receptors in competition with a soluble form of the receptor (sIL-7Rα). We hypothesized that altered sIL-7Rα levels may cause adverse outcomes in patients undergoing HSCT. In parallel, we investigated the impact of the IL-7Rα SNP rs6897932, which has been associated with release of IL-7R.The sIL-7Rα levels decreased during HSCT (from 114. ng/ml before to 48. ng/ml at day +. 14 (P <. 0.0001)). This pattern was inversely mirrored by IL-7. The IL-7/sIL-7Rα ratio at day +. 14 was significantly higher in patients developing grade II-IV aGVHD (OR = 4.3, P = 0.026). Furthermore, donor carriage of the rs6897932 T allele was associated with reduced sIL-7Rα levels, increased risk of grades II-IV aGVHD (OR = 2.4, P = 0.055) and increased transplant-related mortality (CC = 4.5%, CT = 21.4% and TT = 27.3%, P = 0.0037). In conclusion, this study suggests an impact of sIL-7Rα levels and rs6897932 donor genotype on alloreactivity and outcome after HSCT.

OriginalsprogEngelsk
TidsskriftClinical Immunology
Vol/bind187
Sider (fra-til)26-32
ISSN1521-6616
DOI
StatusUdgivet - 2018

ID: 188486472