Adsorption of multimeric T cell antigens on carbon nanotubes: effect on protein structure and antigen-specific T cell stimulation

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Tarek R Fadel, Nan Li, Smith Shah, Michael Look, Lisa D Pfefferle, Gary L Haller, Sune Justesen, Corey J Wilson, Tarek M Fahmy

Antigen-specific activation of cytotoxic T cells can be enhanced up to three-fold more than soluble controls when using functionalized bundled carbon nanotube substrates ((b) CNTs). To overcome the denaturing effects of direct adsorption on (b) CNTs, a simple but robust method is demonstrated to stabilize the T cell stimulus on carbon nanotube substrates through non-covalent attachment of the linker neutravidin.
OriginalsprogEngelsk
TidsskriftSmall
Vol/bind9
Udgave nummer5
Sider (fra-til)666-72
Antal sider7
DOI
StatusUdgivet - 11 mar. 2013

ID: 46307381