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Effect of lifelong resveratrol supplementation and exercise training on skeletal muscle oxidative capacity in aging mice: impact of PGC-1α

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Stine Ringholm, Jesper Olesen, Jesper Thorhauge Pedersen, Christina Tingbjerg Brandt, Jens Frey Halling, Ylva Hellsten, Clara Prats Gavalda, Henriette Pilegaard

The present study tested the hypothesis that lifelong resveratrol (RSV) supplementation counteracts an age-associated decrease in skeletal muscle oxidative capacity through peroxisome proliferator-activated receptor-γ coactivator (PGC)-1α and that RSV combined with lifelong exercise training (ET) exerts additive effects through PGC-1α in mice.
OriginalsprogEngelsk
TidsskriftExperimental Gerontology
Vol/bind48
Tidsskriftsnummer11
Sider (fra-til)1311-1318
Antal sider8
ISSN0531-5565
DOI
StatusUdgivet - 2013

Bibliografisk note

CURIS 2013 NEXS 225

ID: 50215111