Membrane curvature enables N-Ras lipid anchor sorting to liquid-ordered membrane phases

Publikation: Bidrag til tidsskriftTidsskriftartikel

Jannik Bruun Larsen, Martin Borch Jensen, Vikram Kjøller Bhatia, Søren Ljungberg Pedersen, Thomas Bjørnholm, Lars Iversen, Mark Uline, Igal Szleifer, Knud Jørgen Jensen, Nikos Hatzakis, Dimitrios Stamou

Trafficking and sorting of membrane-anchored Ras GTPases are regulated by partitioning between distinct membrane domains. Here, in vitro experiments and microscopic molecular theory reveal membrane curvature as a new modulator of N-Ras lipid anchor and palmitoyl chain partitioning. Membrane curvature was essential for enrichment in raft-like liquid-ordered phases; enrichment was driven by relief of lateral pressure upon anchor insertion and most likely affects the localization of lipidated proteins in general.

OriginalsprogEngelsk
TidsskriftNature Chemical Biology
Vol/bind11
Udgave nummer3
Sider (fra-til)192-194
Antal sider3
ISSN1552-4450
DOI
StatusUdgivet - 2015

ID: 131361806