Body iron is a contributor to oxidative damage of DNA

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T.P. Tuomainen, Steffen Huitfeldt Loft, K. Nyyssonen, K. Punnonen, J.T. Salonen, Henrik Enghusen Poulsen, Tomi-Pekka Tuomainen, Steffen Loft, Kristiina Nyyssönen, Kari Punnonen, Jukka T Salonen, Henrik E Poulsen

The transition metal iron is catalytically highly active in vitro, and not surprisingly, body iron has been suggested to promote oxidative stress in vivo. In the current analysis we studied the association of serum ferritin concentration and serum soluble transferrin receptor concentration with daily urinary 8-hydroxydeoxyguanosine excretion, a marker of oxidative stress, in 48 mildly dyslipidemic men in East Finland. In multivariate linear regression analyses allowing for age, smoking, body mass index and physical exercise, serum ferritin concentration predicted the excretion rate at B = 0.17 (95% CI 0.08-0.26, P = 0.001), and serum soluble transferrin receptor to ferritin concentration ratio (TfR/ferritin) predicted the excretion rate at B = - 0.13 (95% CI - 0.21 to - 0.05, P = 0.002). Our data suggest that body iron contributes to excess oxidative stress already at non-iron overload concentrations in these subjects.
OriginalsprogEngelsk
TidsskriftFree Radical Research
Vol/bind41
Udgave nummer3
Sider (fra-til)324-8
Antal sider5
ISSN1071-5762
DOI
StatusUdgivet - 2007

ID: 4043259