Synthesis of enantiopure 3-substituted morpholines

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Jan Bornholdt, Jakob Felding, Jesper Langgaard Kristensen

Enantiopure 3-substituted morpholines were assembled through ring-opening of a N-2-benzothiazolesulfonyl (Bts) activated aziridine with organocuprates followed by a ring annulation reaction with a vinylsulfonium salt under microwave conditions. Deprotection of the N-Bts group proceeds under very mild conditions with 2-mercaptoacetic acid and LiOH at rt.
OriginalsprogEngelsk
TidsskriftJournal of Organic Chemistry
Vol/bind75
Udgave nummer21
Sider (fra-til)7454-7457
ISSN0022-3263
DOI
StatusUdgivet - 2010

ID: 22796243