Mechanisms of humoral immune response against Pseudomonas aeruginosa biofilm infection in cystic fibrosis

Publikation: Bidrag til tidsskriftReviewForskningfagfællebedømt

Renan Marrichi Mauch, Peter Østrup Jensen, Claus Moser, Carlos Emilio Levy, Niels Høiby

P. aeruginosa chronic lung infection is the major cause of morbidity and mortality in patients with cystic fibrosis (CF), and is characterized by a biofilm mode of growth, increased levels of specific IgG antibodies and immune complex formation. However, despite being designed to combat this infection, such elevated humoral response is not associated with clinical improvement, pointing to a lack of anti-pseudomonas effectiveness. The mode of action of specific antibodies, as well as their structural features, and even the background involving B-cell production, stimulation and differentiation into antibody-producing cells in the CF airways are poorly understood. Thus, the aim of this review is to discuss studies that have addressed the intrinsic features of the humoral immune response and provide new insights regarding its insufficiency in the CF context.

OriginalsprogEngelsk
TidsskriftJournal of cystic fibrosis : official journal of the European Cystic Fibrosis Society
Vol/bind17
Udgave nummer2
Sider (fra-til)143-152
ISSN1569-1993
DOI
StatusUdgivet - 2018

ID: 187078876