Use of intracranial pressure monitoring in bacterial meningitis: a 10-year follow up on outcome and intracranial pressure versus head CT scans

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Standard

Use of intracranial pressure monitoring in bacterial meningitis : a 10-year follow up on outcome and intracranial pressure versus head CT scans. / Larsen, Lykke; Poulsen, Frantz R; Nielsen, Troels H; Nordström, Carl-Henrik; Schulz, Mette K; Andersen, Åse B.

I: Infectious diseases (London, England), Bind 49, Nr. 5, 2017, s. 356-364.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Larsen, L, Poulsen, FR, Nielsen, TH, Nordström, C-H, Schulz, MK & Andersen, ÅB 2017, 'Use of intracranial pressure monitoring in bacterial meningitis: a 10-year follow up on outcome and intracranial pressure versus head CT scans', Infectious diseases (London, England), bind 49, nr. 5, s. 356-364. https://doi.org/10.1080/23744235.2016.1269265

APA

Larsen, L., Poulsen, F. R., Nielsen, T. H., Nordström, C-H., Schulz, M. K., & Andersen, Å. B. (2017). Use of intracranial pressure monitoring in bacterial meningitis: a 10-year follow up on outcome and intracranial pressure versus head CT scans. Infectious diseases (London, England), 49(5), 356-364. https://doi.org/10.1080/23744235.2016.1269265

Vancouver

Larsen L, Poulsen FR, Nielsen TH, Nordström C-H, Schulz MK, Andersen ÅB. Use of intracranial pressure monitoring in bacterial meningitis: a 10-year follow up on outcome and intracranial pressure versus head CT scans. Infectious diseases (London, England). 2017;49(5):356-364. https://doi.org/10.1080/23744235.2016.1269265

Author

Larsen, Lykke ; Poulsen, Frantz R ; Nielsen, Troels H ; Nordström, Carl-Henrik ; Schulz, Mette K ; Andersen, Åse B. / Use of intracranial pressure monitoring in bacterial meningitis : a 10-year follow up on outcome and intracranial pressure versus head CT scans. I: Infectious diseases (London, England). 2017 ; Bind 49, Nr. 5. s. 356-364.

Bibtex

@article{3d9a0f0eaffb46f09a3db00d68a7ebee,
title = "Use of intracranial pressure monitoring in bacterial meningitis: a 10-year follow up on outcome and intracranial pressure versus head CT scans",
abstract = "BACKGROUND: The aim of this study was to evaluate the clinical outcome of patients with severe bacterial meningitis where intracranial pressure (ICP) monitoring has been performed.METHODS: A retrospective observational study including patients admitted 1st. January 2005 to 31st. December 2014. Thirty nine patients age 18-89 years were included. All the patients received intensive care with mechanical ventilation, ICP monitoring, sedation, antibiotics and corticosteroids according to current guidelines. Clinical outcome was defined as death during hospitalization or survival at hospital discharge.RESULTS: The most common pathogen was Streptococcus pneumoniae (26; 67{\%}). Thirteen patients died (33{\%}) and neurologic impairment was noted in twenty two (84.6{\%}) surviving patients. In S. pneumoniae cases patients with adverse outcome were significantly older (p = 0.0024) and immunosuppressed (p = 0.034). Lower mean-cerebral perfusion pressure (CPP) was found to correlate with adverse outcome (p = 0.005). Cerebrospinal fluid (CSF) was drained in fourteen patients. Increased ICP (>20 mmHg) was observed in twenty four patients. No significant correlation was found between measured ICP and head CT scans with signs of elevated ICP.CONCLUSIONS: Patients with severe meningitis should be admitted to intensive care units and evaluated for ICP monitoring regardless of head CT findings.",
keywords = "Adolescent, Adult, Aged, Aged, 80 and over, Drug Monitoring/methods, Female, Head/diagnostic imaging, Humans, Intracranial Pressure, Male, Meningitis, Bacterial/drug therapy, Middle Aged, Retrospective Studies, Survival Analysis, Tomography, X-Ray Computed/methods, Treatment Outcome, Young Adult",
author = "Lykke Larsen and Poulsen, {Frantz R} and Nielsen, {Troels H} and Carl-Henrik Nordstr{\"o}m and Schulz, {Mette K} and Andersen, {{\AA}se B}",
year = "2017",
doi = "10.1080/23744235.2016.1269265",
language = "English",
volume = "49",
pages = "356--364",
journal = "Scandinavian Journal of Infectious Diseases",
issn = "0036-5548",
publisher = "Taylor & Francis",
number = "5",

}

RIS

TY - JOUR

T1 - Use of intracranial pressure monitoring in bacterial meningitis

T2 - Scandinavian Journal of Infectious Diseases

AU - Larsen, Lykke

AU - Poulsen, Frantz R

AU - Nielsen, Troels H

AU - Nordström, Carl-Henrik

AU - Schulz, Mette K

AU - Andersen, Åse B

PY - 2017

Y1 - 2017

N2 - BACKGROUND: The aim of this study was to evaluate the clinical outcome of patients with severe bacterial meningitis where intracranial pressure (ICP) monitoring has been performed.METHODS: A retrospective observational study including patients admitted 1st. January 2005 to 31st. December 2014. Thirty nine patients age 18-89 years were included. All the patients received intensive care with mechanical ventilation, ICP monitoring, sedation, antibiotics and corticosteroids according to current guidelines. Clinical outcome was defined as death during hospitalization or survival at hospital discharge.RESULTS: The most common pathogen was Streptococcus pneumoniae (26; 67%). Thirteen patients died (33%) and neurologic impairment was noted in twenty two (84.6%) surviving patients. In S. pneumoniae cases patients with adverse outcome were significantly older (p = 0.0024) and immunosuppressed (p = 0.034). Lower mean-cerebral perfusion pressure (CPP) was found to correlate with adverse outcome (p = 0.005). Cerebrospinal fluid (CSF) was drained in fourteen patients. Increased ICP (>20 mmHg) was observed in twenty four patients. No significant correlation was found between measured ICP and head CT scans with signs of elevated ICP.CONCLUSIONS: Patients with severe meningitis should be admitted to intensive care units and evaluated for ICP monitoring regardless of head CT findings.

AB - BACKGROUND: The aim of this study was to evaluate the clinical outcome of patients with severe bacterial meningitis where intracranial pressure (ICP) monitoring has been performed.METHODS: A retrospective observational study including patients admitted 1st. January 2005 to 31st. December 2014. Thirty nine patients age 18-89 years were included. All the patients received intensive care with mechanical ventilation, ICP monitoring, sedation, antibiotics and corticosteroids according to current guidelines. Clinical outcome was defined as death during hospitalization or survival at hospital discharge.RESULTS: The most common pathogen was Streptococcus pneumoniae (26; 67%). Thirteen patients died (33%) and neurologic impairment was noted in twenty two (84.6%) surviving patients. In S. pneumoniae cases patients with adverse outcome were significantly older (p = 0.0024) and immunosuppressed (p = 0.034). Lower mean-cerebral perfusion pressure (CPP) was found to correlate with adverse outcome (p = 0.005). Cerebrospinal fluid (CSF) was drained in fourteen patients. Increased ICP (>20 mmHg) was observed in twenty four patients. No significant correlation was found between measured ICP and head CT scans with signs of elevated ICP.CONCLUSIONS: Patients with severe meningitis should be admitted to intensive care units and evaluated for ICP monitoring regardless of head CT findings.

KW - Adolescent

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Drug Monitoring/methods

KW - Female

KW - Head/diagnostic imaging

KW - Humans

KW - Intracranial Pressure

KW - Male

KW - Meningitis, Bacterial/drug therapy

KW - Middle Aged

KW - Retrospective Studies

KW - Survival Analysis

KW - Tomography, X-Ray Computed/methods

KW - Treatment Outcome

KW - Young Adult

U2 - 10.1080/23744235.2016.1269265

DO - 10.1080/23744235.2016.1269265

M3 - Journal article

VL - 49

SP - 356

EP - 364

JO - Scandinavian Journal of Infectious Diseases

JF - Scandinavian Journal of Infectious Diseases

SN - 0036-5548

IS - 5

ER -

ID: 196347172