The HTN3-MSANTD3 Fusion Gene Defines a Subset of Acinic Cell Carcinoma of the Salivary Gland

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The HTN3-MSANTD3 Fusion Gene Defines a Subset of Acinic Cell Carcinoma of the Salivary Gland. / Andreasen, Simon; Varma, Sushama; Barasch, Nicholas; Thompson, Lester D R; Miettinen, Markku; Rooper, Lisa; Stelow, Edward B; Agander, Tina K; Seethala, Raja R; Chiosea, Simion I; Homøe, Preben; Wessel, Irene; Larsen, Stine R; Erentaite, Daiva; Bishop, Justin A; Ulhøi, Benedicte P; Kiss, Katalin; Melchior, Linea C; Pollack, Jonathan R; West, Robert B.

I: American Journal of Surgical Pathology, 2019.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Andreasen, S, Varma, S, Barasch, N, Thompson, LDR, Miettinen, M, Rooper, L, Stelow, EB, Agander, TK, Seethala, RR, Chiosea, SI, Homøe, P, Wessel, I, Larsen, SR, Erentaite, D, Bishop, JA, Ulhøi, BP, Kiss, K, Melchior, LC, Pollack, JR & West, RB 2019, 'The HTN3-MSANTD3 Fusion Gene Defines a Subset of Acinic Cell Carcinoma of the Salivary Gland', American Journal of Surgical Pathology. https://doi.org/10.1097/PAS.0000000000001200

APA

Andreasen, S., Varma, S., Barasch, N., Thompson, L. D. R., Miettinen, M., Rooper, L., ... West, R. B. (2019). The HTN3-MSANTD3 Fusion Gene Defines a Subset of Acinic Cell Carcinoma of the Salivary Gland. American Journal of Surgical Pathology. https://doi.org/10.1097/PAS.0000000000001200

Vancouver

Andreasen S, Varma S, Barasch N, Thompson LDR, Miettinen M, Rooper L o.a. The HTN3-MSANTD3 Fusion Gene Defines a Subset of Acinic Cell Carcinoma of the Salivary Gland. American Journal of Surgical Pathology. 2019. https://doi.org/10.1097/PAS.0000000000001200

Author

Andreasen, Simon ; Varma, Sushama ; Barasch, Nicholas ; Thompson, Lester D R ; Miettinen, Markku ; Rooper, Lisa ; Stelow, Edward B ; Agander, Tina K ; Seethala, Raja R ; Chiosea, Simion I ; Homøe, Preben ; Wessel, Irene ; Larsen, Stine R ; Erentaite, Daiva ; Bishop, Justin A ; Ulhøi, Benedicte P ; Kiss, Katalin ; Melchior, Linea C ; Pollack, Jonathan R ; West, Robert B. / The HTN3-MSANTD3 Fusion Gene Defines a Subset of Acinic Cell Carcinoma of the Salivary Gland. I: American Journal of Surgical Pathology. 2019.

Bibtex

@article{2f0bc0766e634fe3bc48eae72a317d30,
title = "The HTN3-MSANTD3 Fusion Gene Defines a Subset of Acinic Cell Carcinoma of the Salivary Gland",
abstract = "The spectrum of tumors arising in the salivary glands is wide and has recently been shown to harbor a network of tumor-specific fusion genes. Acinic cell carcinoma (AciCC) is one of the more frequently encountered types of salivary gland carcinoma, but it has remained a genetic orphan until recently when a fusion between the HTN3 and MSANTD3 genes was described in one case. Neither of these 2 genes is known to be implicated in any other malignancy. This study was undertaken to investigate whether the HTN3-MSANTD3 fusion is a recurrent genetic event in AciCC and whether it is a characteristic of one of its histological variants. Of the 273 AciCCs screened, 9 cases showed rearrangement of MSANTD3 by break-apart fluorescence in situ hybridization, 2 had 1 to 2 extra signals, and 1 had gain, giving a total of 4.4{\%} with MSANTD3 aberrations. In 6 of 7 available cases with MSANTD3 rearrangement, the HTN3-MSANTD3 fusion transcript was demonstrated with real-time polymerase chain reaction . Histologically, all fusion-positive cases were predominantly composed of serous tumor cells growing in solid sheets, with serous tumor cells expressing DOG-1 and the intercalated duct-like cell component being CK7 positive and S-100 positive in 6/9 cases. All but one case arose in the parotid gland, and none of the patients experienced a recurrence during follow-up. In contrast, the case with MSANTD3 gain metastasized to the cervical lymph nodes and lungs. In conclusion, we find the HTN3-MSANTD3 gene fusion to be a recurrent event in AciCC with prominent serous differentiation and an indolent clinical course.",
author = "Simon Andreasen and Sushama Varma and Nicholas Barasch and Thompson, {Lester D R} and Markku Miettinen and Lisa Rooper and Stelow, {Edward B} and Agander, {Tina K} and Seethala, {Raja R} and Chiosea, {Simion I} and Preben Hom{\o}e and Irene Wessel and Larsen, {Stine R} and Daiva Erentaite and Bishop, {Justin A} and Ulh{\o}i, {Benedicte P} and Katalin Kiss and Melchior, {Linea C} and Pollack, {Jonathan R} and West, {Robert B}",
year = "2019",
doi = "10.1097/PAS.0000000000001200",
language = "English",
journal = "American Journal of Surgical Pathology",
issn = "0147-5185",
publisher = "Lippincott Williams & Wilkins",

}

RIS

TY - JOUR

T1 - The HTN3-MSANTD3 Fusion Gene Defines a Subset of Acinic Cell Carcinoma of the Salivary Gland

AU - Andreasen, Simon

AU - Varma, Sushama

AU - Barasch, Nicholas

AU - Thompson, Lester D R

AU - Miettinen, Markku

AU - Rooper, Lisa

AU - Stelow, Edward B

AU - Agander, Tina K

AU - Seethala, Raja R

AU - Chiosea, Simion I

AU - Homøe, Preben

AU - Wessel, Irene

AU - Larsen, Stine R

AU - Erentaite, Daiva

AU - Bishop, Justin A

AU - Ulhøi, Benedicte P

AU - Kiss, Katalin

AU - Melchior, Linea C

AU - Pollack, Jonathan R

AU - West, Robert B

PY - 2019

Y1 - 2019

N2 - The spectrum of tumors arising in the salivary glands is wide and has recently been shown to harbor a network of tumor-specific fusion genes. Acinic cell carcinoma (AciCC) is one of the more frequently encountered types of salivary gland carcinoma, but it has remained a genetic orphan until recently when a fusion between the HTN3 and MSANTD3 genes was described in one case. Neither of these 2 genes is known to be implicated in any other malignancy. This study was undertaken to investigate whether the HTN3-MSANTD3 fusion is a recurrent genetic event in AciCC and whether it is a characteristic of one of its histological variants. Of the 273 AciCCs screened, 9 cases showed rearrangement of MSANTD3 by break-apart fluorescence in situ hybridization, 2 had 1 to 2 extra signals, and 1 had gain, giving a total of 4.4% with MSANTD3 aberrations. In 6 of 7 available cases with MSANTD3 rearrangement, the HTN3-MSANTD3 fusion transcript was demonstrated with real-time polymerase chain reaction . Histologically, all fusion-positive cases were predominantly composed of serous tumor cells growing in solid sheets, with serous tumor cells expressing DOG-1 and the intercalated duct-like cell component being CK7 positive and S-100 positive in 6/9 cases. All but one case arose in the parotid gland, and none of the patients experienced a recurrence during follow-up. In contrast, the case with MSANTD3 gain metastasized to the cervical lymph nodes and lungs. In conclusion, we find the HTN3-MSANTD3 gene fusion to be a recurrent event in AciCC with prominent serous differentiation and an indolent clinical course.

AB - The spectrum of tumors arising in the salivary glands is wide and has recently been shown to harbor a network of tumor-specific fusion genes. Acinic cell carcinoma (AciCC) is one of the more frequently encountered types of salivary gland carcinoma, but it has remained a genetic orphan until recently when a fusion between the HTN3 and MSANTD3 genes was described in one case. Neither of these 2 genes is known to be implicated in any other malignancy. This study was undertaken to investigate whether the HTN3-MSANTD3 fusion is a recurrent genetic event in AciCC and whether it is a characteristic of one of its histological variants. Of the 273 AciCCs screened, 9 cases showed rearrangement of MSANTD3 by break-apart fluorescence in situ hybridization, 2 had 1 to 2 extra signals, and 1 had gain, giving a total of 4.4% with MSANTD3 aberrations. In 6 of 7 available cases with MSANTD3 rearrangement, the HTN3-MSANTD3 fusion transcript was demonstrated with real-time polymerase chain reaction . Histologically, all fusion-positive cases were predominantly composed of serous tumor cells growing in solid sheets, with serous tumor cells expressing DOG-1 and the intercalated duct-like cell component being CK7 positive and S-100 positive in 6/9 cases. All but one case arose in the parotid gland, and none of the patients experienced a recurrence during follow-up. In contrast, the case with MSANTD3 gain metastasized to the cervical lymph nodes and lungs. In conclusion, we find the HTN3-MSANTD3 gene fusion to be a recurrent event in AciCC with prominent serous differentiation and an indolent clinical course.

U2 - 10.1097/PAS.0000000000001200

DO - 10.1097/PAS.0000000000001200

M3 - Journal article

JO - American Journal of Surgical Pathology

JF - American Journal of Surgical Pathology

SN - 0147-5185

ER -

ID: 209634416