The effects of fish oil and high or low linoleic acid intake on fatty acid composition of human peripheral blood mononuclear cells

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Standard

The effects of fish oil and high or low linoleic acid intake on fatty acid composition of human peripheral blood mononuclear cells. / Damsgaard, Camilla Trab; Frøkiær, Hanne; Lauritzen, Lotte.

I: British Journal of Nutrition, Bind 99, Nr. 1, 2008, s. 147-154.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Damsgaard, CT, Frøkiær, H & Lauritzen, L 2008, 'The effects of fish oil and high or low linoleic acid intake on fatty acid composition of human peripheral blood mononuclear cells', British Journal of Nutrition, bind 99, nr. 1, s. 147-154. https://doi.org/10.1017/S0007114507791900

APA

Damsgaard, C. T., Frøkiær, H., & Lauritzen, L. (2008). The effects of fish oil and high or low linoleic acid intake on fatty acid composition of human peripheral blood mononuclear cells. British Journal of Nutrition, 99(1), 147-154. https://doi.org/10.1017/S0007114507791900

Vancouver

Damsgaard CT, Frøkiær H, Lauritzen L. The effects of fish oil and high or low linoleic acid intake on fatty acid composition of human peripheral blood mononuclear cells. British Journal of Nutrition. 2008;99(1):147-154. https://doi.org/10.1017/S0007114507791900

Author

Damsgaard, Camilla Trab ; Frøkiær, Hanne ; Lauritzen, Lotte. / The effects of fish oil and high or low linoleic acid intake on fatty acid composition of human peripheral blood mononuclear cells. I: British Journal of Nutrition. 2008 ; Bind 99, Nr. 1. s. 147-154.

Bibtex

@article{373f8fb0a1c311ddb6ae000ea68e967b,
title = "The effects of fish oil and high or low linoleic acid intake on fatty acid composition of human peripheral blood mononuclear cells",
abstract = "Dietary intake of 18: 2n-6 and 18: 3n-3 may affect endogenous production and incorporation of n-3 long-chain PUFA (LCPUFA) from fish oils (FO). This double-blinded controlled 2 £ 2-factorial 8-week intervention investigates the effects of high and low 18: 2n-6 intake in combination with FO-supplementation on tissue fatty acid composition. Healthy young men (n 64) were randomized to capsules with FO or olive oil (control) (44 (20-56) ml/d) and to either sunflower oil and margarine (S/B) or rapeseed oil and a butter spread (R/K) to provide a high or a low 18: 2n-6 intake. Diet was measured by 4-d weighed dietary records at baseline, during and 8 weeks after the intervention and tissue ncorporation as fatty acid composition of peripheral blood mononuclear cells (PBMC). The fat intervention gave a mean difference in the 18: 2n-6 intake of 73 g/d (95{\%} CI 46, 100) and a similar 18: 3n-3 intake in the groups. The R/K groups had a 02{\%} fatty acid (FA{\%}) (95{\%} CI 00, 04, P¼002) higher content of 22: 5n-3 in the PBMC, a tendency of slightly higher 20: 5n-3 (P¼006), but no more 22: 6n-3 (P¼083) than the S/B groups. FO effectively raised the PBMC content of all n-3 LCPUFA (P,0001). The fat intervention did not markedly influence the effect of FO; the mean PBMC content of n-3 LCPUFA was 103 (SEM 03) FA{\%} in the FO {\th} S/B group and 106 (SEM 02) FA{\%} in the FO {\th} R/K group. In conclusion, increasing the 18: 2n-6 intake did not have any pronounced effect on incorporation of n-3 LCPUFA in PBMC, either alone or with simultaneous FO supplementation.",
author = "Damsgaard, {Camilla Trab} and Hanne Fr{\o}ki{\ae}r and Lotte Lauritzen",
year = "2008",
doi = "10.1017/S0007114507791900",
language = "English",
volume = "99",
pages = "147--154",
journal = "British Journal of Nutrition",
issn = "0007-1145",
publisher = "Cambridge University Press",
number = "1",

}

RIS

TY - JOUR

T1 - The effects of fish oil and high or low linoleic acid intake on fatty acid composition of human peripheral blood mononuclear cells

AU - Damsgaard, Camilla Trab

AU - Frøkiær, Hanne

AU - Lauritzen, Lotte

PY - 2008

Y1 - 2008

N2 - Dietary intake of 18: 2n-6 and 18: 3n-3 may affect endogenous production and incorporation of n-3 long-chain PUFA (LCPUFA) from fish oils (FO). This double-blinded controlled 2 £ 2-factorial 8-week intervention investigates the effects of high and low 18: 2n-6 intake in combination with FO-supplementation on tissue fatty acid composition. Healthy young men (n 64) were randomized to capsules with FO or olive oil (control) (44 (20-56) ml/d) and to either sunflower oil and margarine (S/B) or rapeseed oil and a butter spread (R/K) to provide a high or a low 18: 2n-6 intake. Diet was measured by 4-d weighed dietary records at baseline, during and 8 weeks after the intervention and tissue ncorporation as fatty acid composition of peripheral blood mononuclear cells (PBMC). The fat intervention gave a mean difference in the 18: 2n-6 intake of 73 g/d (95% CI 46, 100) and a similar 18: 3n-3 intake in the groups. The R/K groups had a 02% fatty acid (FA%) (95% CI 00, 04, P¼002) higher content of 22: 5n-3 in the PBMC, a tendency of slightly higher 20: 5n-3 (P¼006), but no more 22: 6n-3 (P¼083) than the S/B groups. FO effectively raised the PBMC content of all n-3 LCPUFA (P,0001). The fat intervention did not markedly influence the effect of FO; the mean PBMC content of n-3 LCPUFA was 103 (SEM 03) FA% in the FO þ S/B group and 106 (SEM 02) FA% in the FO þ R/K group. In conclusion, increasing the 18: 2n-6 intake did not have any pronounced effect on incorporation of n-3 LCPUFA in PBMC, either alone or with simultaneous FO supplementation.

AB - Dietary intake of 18: 2n-6 and 18: 3n-3 may affect endogenous production and incorporation of n-3 long-chain PUFA (LCPUFA) from fish oils (FO). This double-blinded controlled 2 £ 2-factorial 8-week intervention investigates the effects of high and low 18: 2n-6 intake in combination with FO-supplementation on tissue fatty acid composition. Healthy young men (n 64) were randomized to capsules with FO or olive oil (control) (44 (20-56) ml/d) and to either sunflower oil and margarine (S/B) or rapeseed oil and a butter spread (R/K) to provide a high or a low 18: 2n-6 intake. Diet was measured by 4-d weighed dietary records at baseline, during and 8 weeks after the intervention and tissue ncorporation as fatty acid composition of peripheral blood mononuclear cells (PBMC). The fat intervention gave a mean difference in the 18: 2n-6 intake of 73 g/d (95% CI 46, 100) and a similar 18: 3n-3 intake in the groups. The R/K groups had a 02% fatty acid (FA%) (95% CI 00, 04, P¼002) higher content of 22: 5n-3 in the PBMC, a tendency of slightly higher 20: 5n-3 (P¼006), but no more 22: 6n-3 (P¼083) than the S/B groups. FO effectively raised the PBMC content of all n-3 LCPUFA (P,0001). The fat intervention did not markedly influence the effect of FO; the mean PBMC content of n-3 LCPUFA was 103 (SEM 03) FA% in the FO þ S/B group and 106 (SEM 02) FA% in the FO þ R/K group. In conclusion, increasing the 18: 2n-6 intake did not have any pronounced effect on incorporation of n-3 LCPUFA in PBMC, either alone or with simultaneous FO supplementation.

U2 - 10.1017/S0007114507791900

DO - 10.1017/S0007114507791900

M3 - Journal article

VL - 99

SP - 147

EP - 154

JO - British Journal of Nutrition

JF - British Journal of Nutrition

SN - 0007-1145

IS - 1

ER -

ID: 8089128