Temocene: the porphycene analogue of temoporfin (Foscan®)

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Maria Garcia-Diaz, David Sanchez-Garcia, Santi Nonell, Jorge Soriano, Angeles Villanueva, Juan Carlos Stockert, Magdalena Canete, Maria Lluisa Sagrista, Margarita Mora

Temocene, a porphycene analogue of temoporfin, has been synthesized. Compared to temoporfin, temocene is endowed with 2.5-fold larger absorption coefficients in the red part of the spectrum while keeping its excellent photophysical and singlet oxygen photosensitization ability. While its photodynamic activity towards HeLa cells is lower than that of temoporfin, its higher photostability, lower dark toxicity and mitochondrial localisation make temocene a promising candidate for photodynamic therapy applications.
OriginalsprogEngelsk
TidsskriftMedChemComm
Vol/bind2
Udgave nummer7
Sider (fra-til)616-619
Antal sider4
ISSN2040-2503
DOI
StatusUdgivet - 1 jul. 2011
Eksternt udgivetJa

ID: 46457104