Synthesis of the thiazole-thiazoline fragment of largazole analogues

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Frederik Diness, Daniel Skovhaur Nielsen, David P Fairlie

The thiazole-thiazoline fragment of the marine natural product largazole, a potent histone deacetylase 1 inhibitor, has been synthesized in five steps. The methodology provides rapid access to thiazole-4-carbonitrile, thiazole-4-carbimidate, thiazole-oxazoline, and other thiazole-thiazoline derivatives that are important intermediates in the total synthesis of many natural products with important biological properties.
OriginalsprogEngelsk
TidsskriftJournal of Organic Chemistry
Vol/bind76
Udgave nummer23
Sider (fra-til)9845-9851
ISSN0022-3263
DOI
StatusUdgivet - 2 dec. 2011

ID: 35442124