Structural basis of cell-cell adhesion by NCAM

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

C Kasper, H Rasmussen, Jette Sandholm Jensen Kastrup, S Ikemizu, E Y Jones, V Berezin, E Bock, I K Larsen

The neural cell adhesion molecule NCAM, a member of the immunoglobulin superfamily, mediates cell-cell recognition and adhesion via a homophilic interaction. NCAM plays a key role during development and regeneration of the nervous system and is involved in synaptic plasticity associated with memory and learning. The 1.85 A crystal structure of the two N-terminal extracellular domains of NCAM reported here provides a structural basis for the homophilic interaction. The molecular packing of the two-domain structure reveals a cross shaped antiparallel dimer, and provides fundamental insight into trans-cellular recognition mediated by NCAM.
OriginalsprogEngelsk
TidsskriftNature Structural and Molecular Biology
Vol/bind7
Udgave nummer5
Sider (fra-til)389-393
Antal sider5
ISSN1545-9993
DOI
StatusUdgivet - 2000

ID: 177814