Spontaneous cytotoxic T-Cell reactivity against indoleamine 2,3-dioxygenase-2

Publikation: Bidrag til tidsskriftTidsskriftartikel

Standard

Spontaneous cytotoxic T-Cell reactivity against indoleamine 2,3-dioxygenase-2. / Sørensen, Rikke Bæk; Køllgaard, Tania; Andersen, Rikke Sick; van den Berg, Joost Huibert; Svane, Inge Marie; Straten, Per thor; Andersen, Mads Hald.

I: Cancer Research, Bind 71, Nr. 6, 15.03.2011, s. 2038-44.

Publikation: Bidrag til tidsskriftTidsskriftartikel

Harvard

Sørensen, RB, Køllgaard, T, Andersen, RS, van den Berg, JH, Svane, IM, Straten, PT & Andersen, MH 2011, 'Spontaneous cytotoxic T-Cell reactivity against indoleamine 2,3-dioxygenase-2', Cancer Research, bind 71, nr. 6, s. 2038-44. https://doi.org/10.1158/0008-5472.CAN-10-3403

APA

Sørensen, R. B., Køllgaard, T., Andersen, R. S., van den Berg, J. H., Svane, I. M., Straten, P. T., & Andersen, M. H. (2011). Spontaneous cytotoxic T-Cell reactivity against indoleamine 2,3-dioxygenase-2. Cancer Research, 71(6), 2038-44. https://doi.org/10.1158/0008-5472.CAN-10-3403

Vancouver

Sørensen RB, Køllgaard T, Andersen RS, van den Berg JH, Svane IM, Straten PT o.a. Spontaneous cytotoxic T-Cell reactivity against indoleamine 2,3-dioxygenase-2. Cancer Research. 2011 mar 15;71(6):2038-44. https://doi.org/10.1158/0008-5472.CAN-10-3403

Author

Sørensen, Rikke Bæk ; Køllgaard, Tania ; Andersen, Rikke Sick ; van den Berg, Joost Huibert ; Svane, Inge Marie ; Straten, Per thor ; Andersen, Mads Hald. / Spontaneous cytotoxic T-Cell reactivity against indoleamine 2,3-dioxygenase-2. I: Cancer Research. 2011 ; Bind 71, Nr. 6. s. 2038-44.

Bibtex

@article{b943ff29d6684c07968155d8ac493713,
title = "Spontaneous cytotoxic T-Cell reactivity against indoleamine 2,3-dioxygenase-2",
abstract = "Several lines of data have suggested a possible link between the indoleamine 2,3-dioxygenase (IDO)-like protein IDO2 and cancer. First, IDO2 expression has been described in human tumors, including renal, gastric, colon, and pancreatic tumors. Second, the apparent selective inhibition of IDO2 by the D stereoisomer of the IDO blocker 1-methyl-tryptophan (1MT), which tends to be more active than the L-isomer in a variety of biological assays for IDO function, suggests that IDO2 may be important to sustain immune escape and growth of tumors. Especially, D-1MT heightens chemotherapeutic efficacy in mouse models of cancer in a nontoxic fashion. Here, we describe the immunogenicity of IDO2 by showing the presence of spontaneous cytotoxic T-cell reactivity against IDO2 in peripheral blood of both healthy donors and cancer patients. Furthermore, we show that these IDO2-specific T cells are cytotoxic effector cells that recognize and kill tumor cells. Our data suggest that IDO2 might be a useful target for anticancer immunotherapeutic strategies.",
author = "S{\o}rensen, {Rikke B{\ae}k} and Tania K{\o}llgaard and Andersen, {Rikke Sick} and {van den Berg}, {Joost Huibert} and Svane, {Inge Marie} and Straten, {Per thor} and Andersen, {Mads Hald}",
note = "{\circledC}2011 AACR",
year = "2011",
month = "3",
day = "15",
doi = "http://dx.doi.org/10.1158/0008-5472.CAN-10-3403",
language = "English",
volume = "71",
pages = "2038--44",
journal = "Cancer Research",
issn = "0008-5472",
publisher = "American Association for Cancer Research",
number = "6",

}

RIS

TY - JOUR

T1 - Spontaneous cytotoxic T-Cell reactivity against indoleamine 2,3-dioxygenase-2

AU - Sørensen, Rikke Bæk

AU - Køllgaard, Tania

AU - Andersen, Rikke Sick

AU - van den Berg, Joost Huibert

AU - Svane, Inge Marie

AU - Straten, Per thor

AU - Andersen, Mads Hald

N1 - ©2011 AACR

PY - 2011/3/15

Y1 - 2011/3/15

N2 - Several lines of data have suggested a possible link between the indoleamine 2,3-dioxygenase (IDO)-like protein IDO2 and cancer. First, IDO2 expression has been described in human tumors, including renal, gastric, colon, and pancreatic tumors. Second, the apparent selective inhibition of IDO2 by the D stereoisomer of the IDO blocker 1-methyl-tryptophan (1MT), which tends to be more active than the L-isomer in a variety of biological assays for IDO function, suggests that IDO2 may be important to sustain immune escape and growth of tumors. Especially, D-1MT heightens chemotherapeutic efficacy in mouse models of cancer in a nontoxic fashion. Here, we describe the immunogenicity of IDO2 by showing the presence of spontaneous cytotoxic T-cell reactivity against IDO2 in peripheral blood of both healthy donors and cancer patients. Furthermore, we show that these IDO2-specific T cells are cytotoxic effector cells that recognize and kill tumor cells. Our data suggest that IDO2 might be a useful target for anticancer immunotherapeutic strategies.

AB - Several lines of data have suggested a possible link between the indoleamine 2,3-dioxygenase (IDO)-like protein IDO2 and cancer. First, IDO2 expression has been described in human tumors, including renal, gastric, colon, and pancreatic tumors. Second, the apparent selective inhibition of IDO2 by the D stereoisomer of the IDO blocker 1-methyl-tryptophan (1MT), which tends to be more active than the L-isomer in a variety of biological assays for IDO function, suggests that IDO2 may be important to sustain immune escape and growth of tumors. Especially, D-1MT heightens chemotherapeutic efficacy in mouse models of cancer in a nontoxic fashion. Here, we describe the immunogenicity of IDO2 by showing the presence of spontaneous cytotoxic T-cell reactivity against IDO2 in peripheral blood of both healthy donors and cancer patients. Furthermore, we show that these IDO2-specific T cells are cytotoxic effector cells that recognize and kill tumor cells. Our data suggest that IDO2 might be a useful target for anticancer immunotherapeutic strategies.

U2 - http://dx.doi.org/10.1158/0008-5472.CAN-10-3403

DO - http://dx.doi.org/10.1158/0008-5472.CAN-10-3403

M3 - Journal article

VL - 71

SP - 2038

EP - 2044

JO - Cancer Research

JF - Cancer Research

SN - 0008-5472

IS - 6

ER -

ID: 40197095