Simultaneous disulfide and boronic acid ester exchange in dynamic combinatorial libraries

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Dokumenter

Sanna L. Diemer, Morten Kristensen, Brian Rasmussen, Sophie R. Beeren, Michael Pittelkow

Dynamic combinatorial chemistry has emerged as a promising tool for the discovery of complex receptors in supramolecular chemistry. At the heart of dynamic combinatorial chemistry are the reversible reactions that enable the exchange of building blocks between library members in dynamic combinatorial libraries (DCLs) ensuring thermodynamic control over the system. If more than one reversible reaction operates in a single dynamic combinatorial library, the complexity of the system increases dramatically, and so does its possible applications. One can imagine two reversible reactions that operate simultaneously or two reversible reactions that operate independently. Both these scenarios have advantages and disadvantages. In this contribution, we show how disulfide exchange and boronic ester transesterification can function simultaneous in dynamic combinatorial libraries under appropriate conditions. We describe the detailed studies necessary to establish suitable reaction conditions and highlight the analytical techniques appropriate to study this type of system.

OriginalsprogEngelsk
TidsskriftInternational Journal of Molecular Sciences (Online)
Vol/bind16
Udgave nummer9
Sider (fra-til)21858-21872
Antal sider15
ISSN1661-6596
DOI
StatusUdgivet - 2015

Bibliografisk note

Special issue: Supramolecular interactions

Antal downloads er baseret på statistik fra Google Scholar og www.ku.dk


Ingen data tilgængelig

ID: 146243438