Serum insulin-like growth factor 1 in the aging horse

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Serum insulin-like growth factor 1 in the aging horse. / Lygren, Tone; Hansen, Sanni; Langberg, Henning; Fjeldborg, Julie; Jacobsen, Stine; Nielsen, Mette O; Schjerling, Peter; Markussen, Bo; Thomsen, Preben D; Berg, Lise C.

I: Veterinary clinical pathology / American Society for Veterinary Clinical Pathology, Bind 43, Nr. 4, 22.09.2014, s. 557-560.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Lygren, T, Hansen, S, Langberg, H, Fjeldborg, J, Jacobsen, S, Nielsen, MO, Schjerling, P, Markussen, B, Thomsen, PD & Berg, LC 2014, 'Serum insulin-like growth factor 1 in the aging horse', Veterinary clinical pathology / American Society for Veterinary Clinical Pathology, bind 43, nr. 4, s. 557-560. https://doi.org/10.1111/vcp.12201

APA

Lygren, T., Hansen, S., Langberg, H., Fjeldborg, J., Jacobsen, S., Nielsen, M. O., ... Berg, L. C. (2014). Serum insulin-like growth factor 1 in the aging horse. Veterinary clinical pathology / American Society for Veterinary Clinical Pathology, 43(4), 557-560. https://doi.org/10.1111/vcp.12201

Vancouver

Lygren T, Hansen S, Langberg H, Fjeldborg J, Jacobsen S, Nielsen MO o.a. Serum insulin-like growth factor 1 in the aging horse. Veterinary clinical pathology / American Society for Veterinary Clinical Pathology. 2014 sep 22;43(4):557-560. https://doi.org/10.1111/vcp.12201

Author

Lygren, Tone ; Hansen, Sanni ; Langberg, Henning ; Fjeldborg, Julie ; Jacobsen, Stine ; Nielsen, Mette O ; Schjerling, Peter ; Markussen, Bo ; Thomsen, Preben D ; Berg, Lise C. / Serum insulin-like growth factor 1 in the aging horse. I: Veterinary clinical pathology / American Society for Veterinary Clinical Pathology. 2014 ; Bind 43, Nr. 4. s. 557-560.

Bibtex

@article{cc8e2e668f2443ba9494379af6af1d00,
title = "Serum insulin-like growth factor 1 in the aging horse",
abstract = "BACKGROUND: Insulin-like growth factor 1 (IGF-1) has important roles in anabolic processes in the musculoskeletal system and has been reported to decrease with age in both people and horses.OBJECTIVES: The objective of this study was to determine serum IGF-1 levels in the aging horse from early to late adulthood (age range 5-27 years).METHODS: Healthy horses (n = 72) were used in a cross-sectional study, while 37 paired serum samples were available for a longitudinal study. Serum IGF-1 protein was determined using an ELISA kit validated for use in equine samples.RESULTS: No association was found between serum IGF-1 levels and age in the cross-sectional study. In the longitudinal study, a latent variable model fitted to the data revealed that horses in general experienced a 5.2{\%} increase of serum IGF-1 levels over a 5-year period, but horses crossing a change point around 9 years of age between the 2 samples experienced an 11.0{\%} decrease.CONCLUSIONS: In this study, there was no evidence for aging being a factor in changes of IGF-1 levels in an adult and old horse population.",
author = "Tone Lygren and Sanni Hansen and Henning Langberg and Julie Fjeldborg and Stine Jacobsen and Nielsen, {Mette O} and Peter Schjerling and Bo Markussen and Thomsen, {Preben D} and Berg, {Lise C}",
note = "{\circledC} 2014 American Society for Veterinary Clinical Pathology and European Society for Veterinary Clinical Pathology.",
year = "2014",
month = "9",
day = "22",
doi = "10.1111/vcp.12201",
language = "English",
volume = "43",
pages = "557--560",
journal = "Veterinary Clinical Pathology",
issn = "0275-6382",
publisher = "Wiley-Blackwell",
number = "4",

}

RIS

TY - JOUR

T1 - Serum insulin-like growth factor 1 in the aging horse

AU - Lygren, Tone

AU - Hansen, Sanni

AU - Langberg, Henning

AU - Fjeldborg, Julie

AU - Jacobsen, Stine

AU - Nielsen, Mette O

AU - Schjerling, Peter

AU - Markussen, Bo

AU - Thomsen, Preben D

AU - Berg, Lise C

N1 - © 2014 American Society for Veterinary Clinical Pathology and European Society for Veterinary Clinical Pathology.

PY - 2014/9/22

Y1 - 2014/9/22

N2 - BACKGROUND: Insulin-like growth factor 1 (IGF-1) has important roles in anabolic processes in the musculoskeletal system and has been reported to decrease with age in both people and horses.OBJECTIVES: The objective of this study was to determine serum IGF-1 levels in the aging horse from early to late adulthood (age range 5-27 years).METHODS: Healthy horses (n = 72) were used in a cross-sectional study, while 37 paired serum samples were available for a longitudinal study. Serum IGF-1 protein was determined using an ELISA kit validated for use in equine samples.RESULTS: No association was found between serum IGF-1 levels and age in the cross-sectional study. In the longitudinal study, a latent variable model fitted to the data revealed that horses in general experienced a 5.2% increase of serum IGF-1 levels over a 5-year period, but horses crossing a change point around 9 years of age between the 2 samples experienced an 11.0% decrease.CONCLUSIONS: In this study, there was no evidence for aging being a factor in changes of IGF-1 levels in an adult and old horse population.

AB - BACKGROUND: Insulin-like growth factor 1 (IGF-1) has important roles in anabolic processes in the musculoskeletal system and has been reported to decrease with age in both people and horses.OBJECTIVES: The objective of this study was to determine serum IGF-1 levels in the aging horse from early to late adulthood (age range 5-27 years).METHODS: Healthy horses (n = 72) were used in a cross-sectional study, while 37 paired serum samples were available for a longitudinal study. Serum IGF-1 protein was determined using an ELISA kit validated for use in equine samples.RESULTS: No association was found between serum IGF-1 levels and age in the cross-sectional study. In the longitudinal study, a latent variable model fitted to the data revealed that horses in general experienced a 5.2% increase of serum IGF-1 levels over a 5-year period, but horses crossing a change point around 9 years of age between the 2 samples experienced an 11.0% decrease.CONCLUSIONS: In this study, there was no evidence for aging being a factor in changes of IGF-1 levels in an adult and old horse population.

U2 - 10.1111/vcp.12201

DO - 10.1111/vcp.12201

M3 - Journal article

VL - 43

SP - 557

EP - 560

JO - Veterinary Clinical Pathology

JF - Veterinary Clinical Pathology

SN - 0275-6382

IS - 4

ER -

ID: 124549216