Rapid decline in glomerular filtration rate during the first weeks following heart transplantation

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

M Hornum, M Andersen, F Gustafsson, Peter Sandor Oturai, K Sander, S A Mortensen, Bo Friis Feldt-Rasmussen

We hypothesized that a decrease in renal function is seen immediately after heart transplantation (HTX) with little recovery over time. Twelve consecutive patients had their glomerular filtration rate (GFR) measured using (51)Cr-ethylenediaminetetraacetic acid (EDTA) measured GFR (mGFR) before transplantation and at 1, 2, 3, and 26 weeks after transplantation. The mGFR decreased by 28% and 24% during the first 3 and 26 weeks, respectively, with mean blood cyclosporine concentration as an independent risk factor for the decrease in mGFR. The identification of cyclosporine A (CsA) as the most important risk factor for the rapid and sustained decrease in renal function supports the need for more studies on renoprotective strategies immediately after HTX.
OriginalsprogEngelsk
TidsskriftTransplantation Proceedings
Vol/bind43
Udgave nummer5
Sider (fra-til)1904-7
Antal sider4
ISSN0041-1345
DOI
StatusUdgivet - 2011

ID: 40151326