Post-mortem toxicology in young sudden cardiac death victims: A nationwide cohort study

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Standard

Post-mortem toxicology in young sudden cardiac death victims : A nationwide cohort study. / Bjune, Thea; Risgaard, Bjarke; Kruckow, Line; Glinge, Charlotte; Ingemann-Hansen, Ole; Leth, Peter Mygind; Linnet, Kristian; Banner, Jytte; Winkel, Bo Gregers; Tfelt-Hansen, Jacob.

I: Europace, Bind 20, Nr. 4, 01.04.2018, s. 614–621.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Bjune, T, Risgaard, B, Kruckow, L, Glinge, C, Ingemann-Hansen, O, Leth, PM, Linnet, K, Banner, J, Winkel, BG & Tfelt-Hansen, J 2018, 'Post-mortem toxicology in young sudden cardiac death victims: A nationwide cohort study' Europace, bind 20, nr. 4, s. 614–621. https://doi.org/10.1093/europace/euw435

APA

Bjune, T., Risgaard, B., Kruckow, L., Glinge, C., Ingemann-Hansen, O., Leth, P. M., ... Tfelt-Hansen, J. (2018). Post-mortem toxicology in young sudden cardiac death victims: A nationwide cohort study. Europace, 20(4), 614–621. https://doi.org/10.1093/europace/euw435

Vancouver

Bjune T, Risgaard B, Kruckow L, Glinge C, Ingemann-Hansen O, Leth PM o.a. Post-mortem toxicology in young sudden cardiac death victims: A nationwide cohort study. Europace. 2018 apr 1;20(4):614–621. https://doi.org/10.1093/europace/euw435

Author

Bjune, Thea ; Risgaard, Bjarke ; Kruckow, Line ; Glinge, Charlotte ; Ingemann-Hansen, Ole ; Leth, Peter Mygind ; Linnet, Kristian ; Banner, Jytte ; Winkel, Bo Gregers ; Tfelt-Hansen, Jacob. / Post-mortem toxicology in young sudden cardiac death victims : A nationwide cohort study. I: Europace. 2018 ; Bind 20, Nr. 4. s. 614–621.

Bibtex

@article{607e1b4b2fba4ef09c30b08100fdd0de,
title = "Post-mortem toxicology in young sudden cardiac death victims: A nationwide cohort study",
abstract = "Aims: Several drugs increase the risk of ventricular fibrillation and sudden cardiac death (SCD). We aimed to investigate in detail the toxicological findings of all young SCD throughout Denmark.Methods and results: Deaths in persons aged 1-49 years were included over a 10-year period. Death certificates and autopsy reports were retrieved and read to identify cases of sudden death and establish cause of death. All medico-legal autopsied SCD were included and toxicological reports collected. Positive toxicology was defined as the presence of any substance (licit and/or illicit). All toxicological findings had previously been evaluated not to have caused the death (i.e. lethal concentrations were excluded). We identified 620 medico-legal autopsied cases of SCD, of which 77{\%} (n = 477) were toxicologically investigated post-mortem, and 57{\%} (n = 270) had a positive toxicology profile. Sudden cardiac death with positive toxicology had higher rates of sudden arrhythmic death syndrome (SADS), compared with SCD with negative toxicology (56{\%} vs. 42{\%}, P < 0.01). In total, 752 agents were detected, and polypharmacy (defined as the presence of more than one drug) was present in 61{\%} (n = 164), all substances combined. Psychotropic drugs were the most frequent (62{\%}, n = 467), and 82{\%} (n = 385) were in pharmacological or subpharmacological levels.Conclusion: We found that more than half of all toxicologically investigated SCD victims have positive post-mortem toxicological findings, and polypharmacy is displayed in a considerable proportion. SCD with positive toxicology had higher rate of SADS, suggesting that the compounds may play a proarrhythmic role in these cases.",
keywords = "Journal Article",
author = "Thea Bjune and Bjarke Risgaard and Line Kruckow and Charlotte Glinge and Ole Ingemann-Hansen and Leth, {Peter Mygind} and Kristian Linnet and Jytte Banner and Winkel, {Bo Gregers} and Jacob Tfelt-Hansen",
year = "2018",
month = "4",
day = "1",
doi = "10.1093/europace/euw435",
language = "English",
volume = "20",
pages = "614–621",
journal = "Europace",
issn = "1099-5129",
publisher = "Oxford University Press",
number = "4",

}

RIS

TY - JOUR

T1 - Post-mortem toxicology in young sudden cardiac death victims

T2 - A nationwide cohort study

AU - Bjune, Thea

AU - Risgaard, Bjarke

AU - Kruckow, Line

AU - Glinge, Charlotte

AU - Ingemann-Hansen, Ole

AU - Leth, Peter Mygind

AU - Linnet, Kristian

AU - Banner, Jytte

AU - Winkel, Bo Gregers

AU - Tfelt-Hansen, Jacob

PY - 2018/4/1

Y1 - 2018/4/1

N2 - Aims: Several drugs increase the risk of ventricular fibrillation and sudden cardiac death (SCD). We aimed to investigate in detail the toxicological findings of all young SCD throughout Denmark.Methods and results: Deaths in persons aged 1-49 years were included over a 10-year period. Death certificates and autopsy reports were retrieved and read to identify cases of sudden death and establish cause of death. All medico-legal autopsied SCD were included and toxicological reports collected. Positive toxicology was defined as the presence of any substance (licit and/or illicit). All toxicological findings had previously been evaluated not to have caused the death (i.e. lethal concentrations were excluded). We identified 620 medico-legal autopsied cases of SCD, of which 77% (n = 477) were toxicologically investigated post-mortem, and 57% (n = 270) had a positive toxicology profile. Sudden cardiac death with positive toxicology had higher rates of sudden arrhythmic death syndrome (SADS), compared with SCD with negative toxicology (56% vs. 42%, P < 0.01). In total, 752 agents were detected, and polypharmacy (defined as the presence of more than one drug) was present in 61% (n = 164), all substances combined. Psychotropic drugs were the most frequent (62%, n = 467), and 82% (n = 385) were in pharmacological or subpharmacological levels.Conclusion: We found that more than half of all toxicologically investigated SCD victims have positive post-mortem toxicological findings, and polypharmacy is displayed in a considerable proportion. SCD with positive toxicology had higher rate of SADS, suggesting that the compounds may play a proarrhythmic role in these cases.

AB - Aims: Several drugs increase the risk of ventricular fibrillation and sudden cardiac death (SCD). We aimed to investigate in detail the toxicological findings of all young SCD throughout Denmark.Methods and results: Deaths in persons aged 1-49 years were included over a 10-year period. Death certificates and autopsy reports were retrieved and read to identify cases of sudden death and establish cause of death. All medico-legal autopsied SCD were included and toxicological reports collected. Positive toxicology was defined as the presence of any substance (licit and/or illicit). All toxicological findings had previously been evaluated not to have caused the death (i.e. lethal concentrations were excluded). We identified 620 medico-legal autopsied cases of SCD, of which 77% (n = 477) were toxicologically investigated post-mortem, and 57% (n = 270) had a positive toxicology profile. Sudden cardiac death with positive toxicology had higher rates of sudden arrhythmic death syndrome (SADS), compared with SCD with negative toxicology (56% vs. 42%, P < 0.01). In total, 752 agents were detected, and polypharmacy (defined as the presence of more than one drug) was present in 61% (n = 164), all substances combined. Psychotropic drugs were the most frequent (62%, n = 467), and 82% (n = 385) were in pharmacological or subpharmacological levels.Conclusion: We found that more than half of all toxicologically investigated SCD victims have positive post-mortem toxicological findings, and polypharmacy is displayed in a considerable proportion. SCD with positive toxicology had higher rate of SADS, suggesting that the compounds may play a proarrhythmic role in these cases.

KW - Journal Article

U2 - 10.1093/europace/euw435

DO - 10.1093/europace/euw435

M3 - Journal article

VL - 20

SP - 614

EP - 621

JO - Europace

JF - Europace

SN - 1099-5129

IS - 4

ER -

ID: 174934683