Population genomics reveal recent speciation and rapid evolutionary adaptation in polar bears

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Shiping Liu, Eline Lorenzen, Matteo Fumagalli, Bo Li, Kelley Harris, Zijun Xiong, Long Zhou, Thorfinn Sand Korneliussen, Mehmet Somel, Courtney Babbitt, Greg Wray, Jianwen Li, Weiming He, Zhuo Wang, Wenjing Fu, Xueyan Xiang, Claire C. Morgan, Aoife Doherty, Mary J. O'Connell, James O. McInerney & 9 andre Erik W. Born, Love Dalén, Rune Dietz, Ludovic Antoine Alexandre Orlando, Christian Sonne, Guojie Zhang, Rasmus Nielsen, Eske Willerslev, Jun Wang

Polar bears are uniquely adapted to life in the High Arctic and have undergone drastic physiological changes in response to Arctic climates and a hyperlipid diet of primarily marine mammal prey. We analyzed 89 complete genomes of polar bear and brown bear using population genomic modeling and show that the species diverged only 479-343 thousand years BP. We find that genes on the polar bear lineage have been under stronger positive selection than in brown bears; nine of the top 16 genes under strong positive selection are associated with cardiomyopathy and vascular disease, implying important reorganization of the cardiovascular system. One of the genes showing the strongest evidence of selection, APOB, encodes the primary lipoprotein component of low-density lipoprotein (LDL); functional mutations in APOB may explain how polar bears are able to cope with life-long elevated LDL levels that are associated with high risk of heart disease in humans. PAPERCLIP:
OriginalsprogEngelsk
TidsskriftCell
Vol/bind157
Udgave nummer4
Sider (fra-til)785-794
Antal sider10
DOI
StatusUdgivet - 2014

ID: 110471738