Phorbol Rearrangements

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

An alternative procedure for isolation of 4β-phorbol from seeds of Croton tiglium has been developed, and an
artifact containing a furan ring formed by rearrangement of 12,13,20-O-triacylated phorbol derivatives into (6bS,7R,8R,8aS)-2-
(hydroxymethyl)-5,7,9,9-tetramethyl-3,7,8,9,9a,9b-hexahydrocyclopropa[3′,4′]benzo[1′,2′:3,4]cyclohepta[1,2-b]furan-6b,8,8atriol
(8a) has been characterized. A mechanism involving an oxidative rearrangement and a decarboxylation for formation of the
artifact is proposed.
OriginalsprogEngelsk
TidsskriftJournal of Natural Products
Vol/bind81
Udgave nummer9
Sider (fra-til)2134-2137
Antal sider4
ISSN0163-3864
DOI
StatusUdgivet - 15 sep. 2018

ID: 202426226