Novel 7-phenylsulfanyl-1,2,3,4,10,10a-hexahydro-pyrazino[1,2-a]indoles as dual serotonin 5-HT2C and 5-HT6 receptor ligands

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Niels Krogsgaard-Larsen, Anders A. Jensen, Jan Kehler

Novel 7-phenylsulfanyl-1,2,3,4,10,10a-hexahydro-pyrazino[1,2-a]indoles are synthesized using a six-step protocol. Notably, the synthesis route make use of a new and improved ring-closing methodology for the assembly of the hexahydro-pyrazino[1,2-a]indole scaffold, which is based on intramolecular C-H insertion of a carbene. The compounds act as dual serotonin 5-HT2C- and 5-HT6-ligands.
OriginalsprogEngelsk
TidsskriftBioorganic & Medicinal Chemistry Letters
Vol/bind20
Udgave nummer18
Sider (fra-til)5431-5433
ISSN0960-894X
DOI
StatusUdgivet - 15 sep. 2010

Bibliografisk note

Keywords: carbene, C-H insertion, serotonin, 5-HT2C, 5-HT6, 1,2,3,4,10,10a-hexahydro-pyrazino[1,2-a]indole

ID: 34207860