Natriuretic peptides and cerebral hemodynamics

Publikation: Bidrag til tidsskriftReviewForskningfagfællebedømt

Song Guo, Filippa Barringer, Nora Elisabeth Zois, Jens P Goetze, Messoud Ashina

Natriuretic peptides have emerged as important diagnostic and prognostic tools for cardiovascular disease. Plasma measurement of the bioactive peptides as well as precursor-derived fragments is a sensitive tool in assessing heart failure. In heart failure, the peptides are used as treatment in decompensated disease. In contrast, their biological effects on the cerebral hemodynamics are poorly understood. In this mini-review, we summarize the hemodynamic effects of the natriuretic peptides with a focus on the cerebral hemodynamics. In addition, we will discuss its potential implications in diseases where alteration of the cerebral hemodynamics plays a role such as migraine and acute brain injury including stroke. We conclude that a possible role of the peptides is feasible as evaluated from animal and in vitro studies, but more research is needed in humans to determine the precise response on cerebral vessels.

OriginalsprogEngelsk
TidsskriftRegulatory Peptides
Vol/bind192-193
Sider (fra-til)15-23
Antal sider9
ISSN0167-0115
DOI
StatusUdgivet - 2014

ID: 137630240