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Loss-of-function variants in ADCY3 increase risk of obesity and type 2 diabetes

Publikation: Bidrag til tidsskriftTidsskriftartikel

Niels Grarup, Ida Moltke, Mette Korre Andersen, Maria Dalby, Kristoffer Vitting-Seerup, Timo Sebastian Kern, Yuvaraj Mahendran, Emil Jørsboe, Christina Viskum Lytken Larsen, Inger Katrine Dahl-Petersen, Arthur Gilly, Daniel Suveges, George Dedoussis, Eleftheria Zeggini, Oluf Borbye Pedersen, Robin Andersson, Peter Bjerregaard, Marit Eika Jørgensen, Anders Albrechtsen, Torben Hansen

We have identified a variant in ADCY3 (encoding adenylate cyclase 3) associated with markedly increased risk of obesity and type 2 diabetes in the Greenlandic population. The variant disrupts a splice acceptor site, and carriers have decreased ADCY3 RNA expression. Additionally, we observe an enrichment of rare ADCY3 loss-of-function variants among individuals with type 2 diabetes in trans-ancestry cohorts. These findings provide new information on disease etiology relevant for future treatment strategies.

OriginalsprogEngelsk
TidsskriftNature genetics
Vol/bind50
Tidsskriftsnummer2
Sider (fra-til)172-174
Antal sider3
ISSN1061-4036
DOI
StatusUdgivet - 2018

ID: 191301970