Local administration of insulin-like growth factor-I (IGF-I) stimulates tendon collagen synthesis in humans

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M Hansen, A Boesen, L Holm, A Flyvbjerg, Henning Langberg, M Kjaer

Collagen is the predominant structural protein in tendons and ligaments, and can be controlled by hormonal changes. In animals, injections of insulin-like growth factor I (IGF-I) has been shown to increase collagen synthesis in tendons and ligaments and to improve structural tissue healing, but the effect of local IGF-I administration on tendon collagen synthesis in human has not been studied. The purpose of this study was to study whether local injections of IGF-I would have a stimulating effect on tendon collagen synthesis. Twelve healthy nonsmoking men [age 62¿±¿1¿years (mean¿±¿SEM), BMI 27¿±¿1] participated. Two injections of either human recombinant IGF-I (0.1¿mL Increlex©) or saline (control) into each patellar tendon were performed 24-h apart, respectively. Tendon collagen fractional synthesis rate (FSR) was measured by stable isotope technique in the hours after the second injection. Simultaneously, interstitial peritendinous (IGF-I) and [procollagen type I N-terminal propeptide (PINP)], as a marker for type I collagen synthesis, were determined by microdialysis technique. Tendon collagen FSR and PINP were significantly higher in the IGF-I leg compared with the control leg (P¿
OriginalsprogEngelsk
TidsskriftScandinavian Journal of Medicine & Science in Sports
ISSN0905-7188
DOI
StatusUdgivet - 2013

ID: 122548230