Isolation of immunomodulatory triterpene acids from a standardized rose hip powder (Rosa canina L.)

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Standard

Isolation of immunomodulatory triterpene acids from a standardized rose hip powder (Rosa canina L.). / Saaby, Lasse; Jäger, Anna Katharina; Moesby, Lise; Hansen, Erik Wind; Christensen, Søren Brøgger.

I: Phytotherapy Research, Bind 25, Nr. 2, 02.2011, s. 195-201.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Saaby, L, Jäger, AK, Moesby, L, Hansen, EW & Christensen, SB 2011, 'Isolation of immunomodulatory triterpene acids from a standardized rose hip powder (Rosa canina L.)', Phytotherapy Research, bind 25, nr. 2, s. 195-201. https://doi.org/10.1002/ptr.3241

APA

Saaby, L., Jäger, A. K., Moesby, L., Hansen, E. W., & Christensen, S. B. (2011). Isolation of immunomodulatory triterpene acids from a standardized rose hip powder (Rosa canina L.). Phytotherapy Research, 25(2), 195-201. https://doi.org/10.1002/ptr.3241

Vancouver

Saaby L, Jäger AK, Moesby L, Hansen EW, Christensen SB. Isolation of immunomodulatory triterpene acids from a standardized rose hip powder (Rosa canina L.). Phytotherapy Research. 2011 feb;25(2):195-201. https://doi.org/10.1002/ptr.3241

Author

Saaby, Lasse ; Jäger, Anna Katharina ; Moesby, Lise ; Hansen, Erik Wind ; Christensen, Søren Brøgger. / Isolation of immunomodulatory triterpene acids from a standardized rose hip powder (Rosa canina L.). I: Phytotherapy Research. 2011 ; Bind 25, Nr. 2. s. 195-201.

Bibtex

@article{52ba0ab0bbf511df825b000ea68e967b,
title = "Isolation of immunomodulatory triterpene acids from a standardized rose hip powder (Rosa canina L.)",
abstract = "A previously published systematic review and a metaanalysis have concluded that the consumption of standardized rose hip powder (Rosa canina L.) can reduce pain in osteoarthritis patients. Synovial inflammation has been suggested to play an important role in the pathogenesis of osteoarthritis and mainly to involve infiltration of the synovial membrane by macrophages. Therefore, the immunomodulatory effect of standardized rose hip powder of Rosa canina L. was investigated and active principles isolated using the Mono Mac 6 cell line as a model for human macrophages. Treatment of Mono Mac 6 cells with the residue of a crude dichloromethane extract of rose hip powder significantly and concentration dependently inhibited the lipopolysaccharide induced interleukin-6 release. Through bioassay-guided fractionation the immunomodulatory effect of the dichloromethane extract was correlated to a mixture of three triterpene acids; oleanolic acid, betulinic acid and ursolic acid (IC(50) 21 +/- 6 microm). Further studies revealed that only oleanolic acid and ursolic acid, but not betulinic acid, could inhibit the lipopolysaccharide induced interleukin-6 release from Mono Mac 6 cells when tested separately. Combination of either oleanolic acid or ursolic acid with betulinic acid enhanced the immunomodulatory effect of the two triterpene acids. Copyright (c) 2010 John Wiley & Sons, Ltd.",
keywords = "The Faculty of Pharmaceutical Sciences",
author = "Lasse Saaby and J{\"a}ger, {Anna Katharina} and Lise Moesby and Hansen, {Erik Wind} and Christensen, {S{\o}ren Br{\o}gger}",
note = "Keywords: Rosa canina L.; Mono Mac 6; interleukin-6; triterpene acid; rose hip powder.",
year = "2011",
month = "2",
doi = "10.1002/ptr.3241",
language = "English",
volume = "25",
pages = "195--201",
journal = "Phytotherapy Research",
issn = "0951-418X",
publisher = "JohnWiley & Sons Ltd",
number = "2",

}

RIS

TY - JOUR

T1 - Isolation of immunomodulatory triterpene acids from a standardized rose hip powder (Rosa canina L.)

AU - Saaby, Lasse

AU - Jäger, Anna Katharina

AU - Moesby, Lise

AU - Hansen, Erik Wind

AU - Christensen, Søren Brøgger

N1 - Keywords: Rosa canina L.; Mono Mac 6; interleukin-6; triterpene acid; rose hip powder.

PY - 2011/2

Y1 - 2011/2

N2 - A previously published systematic review and a metaanalysis have concluded that the consumption of standardized rose hip powder (Rosa canina L.) can reduce pain in osteoarthritis patients. Synovial inflammation has been suggested to play an important role in the pathogenesis of osteoarthritis and mainly to involve infiltration of the synovial membrane by macrophages. Therefore, the immunomodulatory effect of standardized rose hip powder of Rosa canina L. was investigated and active principles isolated using the Mono Mac 6 cell line as a model for human macrophages. Treatment of Mono Mac 6 cells with the residue of a crude dichloromethane extract of rose hip powder significantly and concentration dependently inhibited the lipopolysaccharide induced interleukin-6 release. Through bioassay-guided fractionation the immunomodulatory effect of the dichloromethane extract was correlated to a mixture of three triterpene acids; oleanolic acid, betulinic acid and ursolic acid (IC(50) 21 +/- 6 microm). Further studies revealed that only oleanolic acid and ursolic acid, but not betulinic acid, could inhibit the lipopolysaccharide induced interleukin-6 release from Mono Mac 6 cells when tested separately. Combination of either oleanolic acid or ursolic acid with betulinic acid enhanced the immunomodulatory effect of the two triterpene acids. Copyright (c) 2010 John Wiley & Sons, Ltd.

AB - A previously published systematic review and a metaanalysis have concluded that the consumption of standardized rose hip powder (Rosa canina L.) can reduce pain in osteoarthritis patients. Synovial inflammation has been suggested to play an important role in the pathogenesis of osteoarthritis and mainly to involve infiltration of the synovial membrane by macrophages. Therefore, the immunomodulatory effect of standardized rose hip powder of Rosa canina L. was investigated and active principles isolated using the Mono Mac 6 cell line as a model for human macrophages. Treatment of Mono Mac 6 cells with the residue of a crude dichloromethane extract of rose hip powder significantly and concentration dependently inhibited the lipopolysaccharide induced interleukin-6 release. Through bioassay-guided fractionation the immunomodulatory effect of the dichloromethane extract was correlated to a mixture of three triterpene acids; oleanolic acid, betulinic acid and ursolic acid (IC(50) 21 +/- 6 microm). Further studies revealed that only oleanolic acid and ursolic acid, but not betulinic acid, could inhibit the lipopolysaccharide induced interleukin-6 release from Mono Mac 6 cells when tested separately. Combination of either oleanolic acid or ursolic acid with betulinic acid enhanced the immunomodulatory effect of the two triterpene acids. Copyright (c) 2010 John Wiley & Sons, Ltd.

KW - The Faculty of Pharmaceutical Sciences

U2 - 10.1002/ptr.3241

DO - 10.1002/ptr.3241

M3 - Journal article

VL - 25

SP - 195

EP - 201

JO - Phytotherapy Research

JF - Phytotherapy Research

SN - 0951-418X

IS - 2

ER -

ID: 21905283