Introduction to the Glutamate-Glutamine Cycle

Publikation: Bog/antologi/afhandling/rapportAntologiForskningfagfællebedømt

Standard

Introduction to the Glutamate-Glutamine Cycle. / Sonnewald, Ursula; Schousboe, Arne.

2016. 7 s. (Advances in Neurobiology).

Publikation: Bog/antologi/afhandling/rapportAntologiForskningfagfællebedømt

Harvard

Sonnewald, U & Schousboe, A 2016, Introduction to the Glutamate-Glutamine Cycle. Advances in Neurobiology, bind 13. https://doi.org/10.1007/978-3-319-45096-4_1

APA

Sonnewald, U., & Schousboe, A. (2016). Introduction to the Glutamate-Glutamine Cycle. Advances in Neurobiology https://doi.org/10.1007/978-3-319-45096-4_1

Vancouver

Sonnewald U, Schousboe A. Introduction to the Glutamate-Glutamine Cycle. 2016. 7 s. (Advances in Neurobiology). https://doi.org/10.1007/978-3-319-45096-4_1

Author

Sonnewald, Ursula ; Schousboe, Arne. / Introduction to the Glutamate-Glutamine Cycle. 2016. 7 s. (Advances in Neurobiology).

Bibtex

@book{e9b3d59277914bb49493bcb24db7c02c,
title = "Introduction to the Glutamate-Glutamine Cycle",
abstract = "The term 'glutamate-glutamine cycle' was coined several decades ago based on the observation that using certain (14)C-labeled precursors for studies of brain metabolism the specific radioactivity of glutamine generated from glutamate was higher than that of glutamate, its immediate precursor. This is metabolically impossible unless it is assumed that at least two distinct pools of these amino acids exist. This combined with the finding that the enzyme synthesizing glutamine from glutamate was expressed in astrocytes but not in neurons formed the basis of the notion that a cycle must exist in which glutamate released from neurons is transported into astrocytes, converted to glutamine which is subsequently returned to neurons and converted to glutamate by an enzyme the activity of which is much higher in neurons than in astrocytes. Originally this cycle was supposed to function in a stoichiometric fashion but more recent research has seriously questioned this.This volume of Advances in Neurobiology is intended to provide a detailed discussion of recent developments in research aimed at delineating the functional roles of the cycle taking into account that in order for this system to work there must be a tight coupling between metabolism of glutamate in astrocytes, transfer of glutamine to neurons and de novo synthesis of glutamine in astrocytes. To understand this, knowledge about the activity and regulation of the enzymes and transporters involved in these processes is required and as can be seen from the table of contents these issues will be dealt with in detail in the individual chapters of the book.",
author = "Ursula Sonnewald and Arne Schousboe",
year = "2016",
doi = "10.1007/978-3-319-45096-4_1",
language = "English",
volume = "13",

}

RIS

TY - BOOK

T1 - Introduction to the Glutamate-Glutamine Cycle

AU - Sonnewald, Ursula

AU - Schousboe, Arne

PY - 2016

Y1 - 2016

N2 - The term 'glutamate-glutamine cycle' was coined several decades ago based on the observation that using certain (14)C-labeled precursors for studies of brain metabolism the specific radioactivity of glutamine generated from glutamate was higher than that of glutamate, its immediate precursor. This is metabolically impossible unless it is assumed that at least two distinct pools of these amino acids exist. This combined with the finding that the enzyme synthesizing glutamine from glutamate was expressed in astrocytes but not in neurons formed the basis of the notion that a cycle must exist in which glutamate released from neurons is transported into astrocytes, converted to glutamine which is subsequently returned to neurons and converted to glutamate by an enzyme the activity of which is much higher in neurons than in astrocytes. Originally this cycle was supposed to function in a stoichiometric fashion but more recent research has seriously questioned this.This volume of Advances in Neurobiology is intended to provide a detailed discussion of recent developments in research aimed at delineating the functional roles of the cycle taking into account that in order for this system to work there must be a tight coupling between metabolism of glutamate in astrocytes, transfer of glutamine to neurons and de novo synthesis of glutamine in astrocytes. To understand this, knowledge about the activity and regulation of the enzymes and transporters involved in these processes is required and as can be seen from the table of contents these issues will be dealt with in detail in the individual chapters of the book.

AB - The term 'glutamate-glutamine cycle' was coined several decades ago based on the observation that using certain (14)C-labeled precursors for studies of brain metabolism the specific radioactivity of glutamine generated from glutamate was higher than that of glutamate, its immediate precursor. This is metabolically impossible unless it is assumed that at least two distinct pools of these amino acids exist. This combined with the finding that the enzyme synthesizing glutamine from glutamate was expressed in astrocytes but not in neurons formed the basis of the notion that a cycle must exist in which glutamate released from neurons is transported into astrocytes, converted to glutamine which is subsequently returned to neurons and converted to glutamate by an enzyme the activity of which is much higher in neurons than in astrocytes. Originally this cycle was supposed to function in a stoichiometric fashion but more recent research has seriously questioned this.This volume of Advances in Neurobiology is intended to provide a detailed discussion of recent developments in research aimed at delineating the functional roles of the cycle taking into account that in order for this system to work there must be a tight coupling between metabolism of glutamate in astrocytes, transfer of glutamine to neurons and de novo synthesis of glutamine in astrocytes. To understand this, knowledge about the activity and regulation of the enzymes and transporters involved in these processes is required and as can be seen from the table of contents these issues will be dealt with in detail in the individual chapters of the book.

U2 - 10.1007/978-3-319-45096-4_1

DO - 10.1007/978-3-319-45096-4_1

M3 - Anthology

VL - 13

BT - Introduction to the Glutamate-Glutamine Cycle

ER -

ID: 169562613