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In utero exposure to 25-hydroxyvitamin D and risk of childhood asthma, wheeze, and respiratory tract infections: A meta-analysis of birth cohort studies

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In utero exposure to 25-hydroxyvitamin D and risk of childhood asthma, wheeze, and respiratory tract infections : A meta-analysis of birth cohort studies. / Feng, Haixia; Xun, Pengcheng; Pike, Katharine C; Wills, Andrew K; Chawes, Bo L; Bisgaard, Hans; Cai, Wei; Wan, Yanping; He, Ka.

I: The Journal of allergy and clinical immunology, Bind 139, Nr. 5, 05.2017, s. 1508-1517.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Feng, H, Xun, P, Pike, KC, Wills, AK, Chawes, BL, Bisgaard, H, Cai, W, Wan, Y & He, K 2017, 'In utero exposure to 25-hydroxyvitamin D and risk of childhood asthma, wheeze, and respiratory tract infections: A meta-analysis of birth cohort studies' The Journal of allergy and clinical immunology, bind 139, nr. 5, s. 1508-1517. https://doi.org/10.1016/j.jaci.2016.06.065

APA

Feng, H., Xun, P., Pike, K. C., Wills, A. K., Chawes, B. L., Bisgaard, H., ... He, K. (2017). In utero exposure to 25-hydroxyvitamin D and risk of childhood asthma, wheeze, and respiratory tract infections: A meta-analysis of birth cohort studies. The Journal of allergy and clinical immunology, 139(5), 1508-1517. https://doi.org/10.1016/j.jaci.2016.06.065

Vancouver

Feng H, Xun P, Pike KC, Wills AK, Chawes BL, Bisgaard H o.a. In utero exposure to 25-hydroxyvitamin D and risk of childhood asthma, wheeze, and respiratory tract infections: A meta-analysis of birth cohort studies. The Journal of allergy and clinical immunology. 2017 maj;139(5):1508-1517. https://doi.org/10.1016/j.jaci.2016.06.065

Author

Feng, Haixia ; Xun, Pengcheng ; Pike, Katharine C ; Wills, Andrew K ; Chawes, Bo L ; Bisgaard, Hans ; Cai, Wei ; Wan, Yanping ; He, Ka. / In utero exposure to 25-hydroxyvitamin D and risk of childhood asthma, wheeze, and respiratory tract infections : A meta-analysis of birth cohort studies. I: The Journal of allergy and clinical immunology. 2017 ; Bind 139, Nr. 5. s. 1508-1517.

Bibtex

@article{8c87d3a1dee6473c9b06572ed6c9f436,
title = "In utero exposure to 25-hydroxyvitamin D and risk of childhood asthma, wheeze, and respiratory tract infections: A meta-analysis of birth cohort studies",
abstract = "BACKGROUND: Studies of the associations between in utero 25-hydroxyvitamin D (25[OH]D) exposure and risk of childhood asthma, wheeze, and respiratory tract infections are inconsistent and inconclusive.OBJECTIVES: We sought to assess associations between 25(OH)D levels in cord blood or maternal venous blood and risk of offspring's asthma, wheeze, and respiratory tract infections.METHODS: Data were derived from PubMed, Embase, Google Scholar, references from relevant articles, and de novo results from published studies until December 2015. A random-effects meta-analysis was conducted among 16 birth cohort studies.RESULTS: Comparing the highest with the lowest category of 25(OH)D levels, the pooled odds ratios were 0.84 (95{\%} CI, 0.70-1.01; P = .064) for asthma, 0.77 (95{\%} CI, 0.58-1.03; P = .083) for wheeze, and 0.85 (95{\%} CI, 0.66-1.09; P = .187) for respiratory tract infections. The observed inverse association for wheeze was more pronounced and became statistically significant in the studies that measured 25(OH)D levels in cord blood (0.43; 95{\%} CI, 0.29-0.62; P < .001).CONCLUSIONS: Accumulated evidence generated from this meta-analysis suggests that increased in utero exposure to 25(OH)D is inversely associated with the risk of asthma and wheeze during childhood. These findings are in keeping with the results of 2 recently published randomized clinical trials of vitamin D supplementation during pregnancy.",
keywords = "Journal Article",
author = "Haixia Feng and Pengcheng Xun and Pike, {Katharine C} and Wills, {Andrew K} and Chawes, {Bo L} and Hans Bisgaard and Wei Cai and Yanping Wan and Ka He",
note = "Copyright {\circledC} 2016 American Academy of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.",
year = "2017",
month = "5",
doi = "10.1016/j.jaci.2016.06.065",
language = "English",
volume = "139",
pages = "1508--1517",
journal = "Journal of Allergy and Clinical Immunology",
issn = "0091-6749",
publisher = "Mosby Inc.",
number = "5",

}

RIS

TY - JOUR

T1 - In utero exposure to 25-hydroxyvitamin D and risk of childhood asthma, wheeze, and respiratory tract infections

T2 - Journal of Allergy and Clinical Immunology

AU - Feng,Haixia

AU - Xun,Pengcheng

AU - Pike,Katharine C

AU - Wills,Andrew K

AU - Chawes,Bo L

AU - Bisgaard,Hans

AU - Cai,Wei

AU - Wan,Yanping

AU - He,Ka

N1 - Copyright © 2016 American Academy of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.

PY - 2017/5

Y1 - 2017/5

N2 - BACKGROUND: Studies of the associations between in utero 25-hydroxyvitamin D (25[OH]D) exposure and risk of childhood asthma, wheeze, and respiratory tract infections are inconsistent and inconclusive.OBJECTIVES: We sought to assess associations between 25(OH)D levels in cord blood or maternal venous blood and risk of offspring's asthma, wheeze, and respiratory tract infections.METHODS: Data were derived from PubMed, Embase, Google Scholar, references from relevant articles, and de novo results from published studies until December 2015. A random-effects meta-analysis was conducted among 16 birth cohort studies.RESULTS: Comparing the highest with the lowest category of 25(OH)D levels, the pooled odds ratios were 0.84 (95% CI, 0.70-1.01; P = .064) for asthma, 0.77 (95% CI, 0.58-1.03; P = .083) for wheeze, and 0.85 (95% CI, 0.66-1.09; P = .187) for respiratory tract infections. The observed inverse association for wheeze was more pronounced and became statistically significant in the studies that measured 25(OH)D levels in cord blood (0.43; 95% CI, 0.29-0.62; P < .001).CONCLUSIONS: Accumulated evidence generated from this meta-analysis suggests that increased in utero exposure to 25(OH)D is inversely associated with the risk of asthma and wheeze during childhood. These findings are in keeping with the results of 2 recently published randomized clinical trials of vitamin D supplementation during pregnancy.

AB - BACKGROUND: Studies of the associations between in utero 25-hydroxyvitamin D (25[OH]D) exposure and risk of childhood asthma, wheeze, and respiratory tract infections are inconsistent and inconclusive.OBJECTIVES: We sought to assess associations between 25(OH)D levels in cord blood or maternal venous blood and risk of offspring's asthma, wheeze, and respiratory tract infections.METHODS: Data were derived from PubMed, Embase, Google Scholar, references from relevant articles, and de novo results from published studies until December 2015. A random-effects meta-analysis was conducted among 16 birth cohort studies.RESULTS: Comparing the highest with the lowest category of 25(OH)D levels, the pooled odds ratios were 0.84 (95% CI, 0.70-1.01; P = .064) for asthma, 0.77 (95% CI, 0.58-1.03; P = .083) for wheeze, and 0.85 (95% CI, 0.66-1.09; P = .187) for respiratory tract infections. The observed inverse association for wheeze was more pronounced and became statistically significant in the studies that measured 25(OH)D levels in cord blood (0.43; 95% CI, 0.29-0.62; P < .001).CONCLUSIONS: Accumulated evidence generated from this meta-analysis suggests that increased in utero exposure to 25(OH)D is inversely associated with the risk of asthma and wheeze during childhood. These findings are in keeping with the results of 2 recently published randomized clinical trials of vitamin D supplementation during pregnancy.

KW - Journal Article

U2 - 10.1016/j.jaci.2016.06.065

DO - 10.1016/j.jaci.2016.06.065

M3 - Journal article

VL - 139

SP - 1508

EP - 1517

JO - Journal of Allergy and Clinical Immunology

JF - Journal of Allergy and Clinical Immunology

SN - 0091-6749

IS - 5

ER -

ID: 178194208