Immunomodulatory effects of excretory/secretory compounds from Contracaecum osculatum larvae in a zebrafish inflammation model

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Standard

Immunomodulatory effects of excretory/secretory compounds from Contracaecum osculatum larvae in a zebrafish inflammation model. / Mehrdana, Foojan; Kania, Per Walter; Nazemi, Sasan; Buchmann, Kurt.

I: PLOS ONE, Bind 12, Nr. 7, e0181277, 2017.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Mehrdana, F, Kania, PW, Nazemi, S & Buchmann, K 2017, 'Immunomodulatory effects of excretory/secretory compounds from Contracaecum osculatum larvae in a zebrafish inflammation model', PLOS ONE, bind 12, nr. 7, e0181277. https://doi.org/10.1371/journal.pone.0181277

APA

Mehrdana, F., Kania, P. W., Nazemi, S., & Buchmann, K. (2017). Immunomodulatory effects of excretory/secretory compounds from Contracaecum osculatum larvae in a zebrafish inflammation model. PLOS ONE, 12(7), [ e0181277]. https://doi.org/10.1371/journal.pone.0181277

Vancouver

Mehrdana F, Kania PW, Nazemi S, Buchmann K. Immunomodulatory effects of excretory/secretory compounds from Contracaecum osculatum larvae in a zebrafish inflammation model. PLOS ONE. 2017;12(7). e0181277. https://doi.org/10.1371/journal.pone.0181277

Author

Mehrdana, Foojan ; Kania, Per Walter ; Nazemi, Sasan ; Buchmann, Kurt. / Immunomodulatory effects of excretory/secretory compounds from Contracaecum osculatum larvae in a zebrafish inflammation model. I: PLOS ONE. 2017 ; Bind 12, Nr. 7.

Bibtex

@article{3b3cd79a191c402da6601e73aa767bbe,
title = "Immunomodulatory effects of excretory/secretory compounds from Contracaecum osculatum larvae in a zebrafish inflammation model",
abstract = "Excretory/secretory (ES) compounds isolated from third-stage larvae of the anisakid nematode Contracaecum osculatum parasitizing liver of Baltic cod were investigated for effects on immune gene expression in a zebrafish LPS-induced inflammation model. ES products containing a series of proteins, of which some had enzymatic activity, were injected solely or with LPS. ES proteins alone induced up-regulation of a number of immune-related genes, but generally to a lower degree compared to LPS. When co-injected with LPS, the worm products exacerbated merely expression of five genes affecting Th1, Th2, Th17 and innate responses compared to the LPS-injected group. However, the level of overexpression decreased in an inverse dose-dependent manner. The immune regulating action of C. osculatum ES products is interpreted as an important evolutionary ability of larval parasites in the transport host which makes it less susceptible to host immune responses whereby the probability of reaching the final host is increased.",
author = "Foojan Mehrdana and Kania, {Per Walter} and Sasan Nazemi and Kurt Buchmann",
year = "2017",
doi = "10.1371/journal.pone.0181277",
language = "English",
volume = "12",
journal = "P L o S One",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "7",

}

RIS

TY - JOUR

T1 - Immunomodulatory effects of excretory/secretory compounds from Contracaecum osculatum larvae in a zebrafish inflammation model

AU - Mehrdana, Foojan

AU - Kania, Per Walter

AU - Nazemi, Sasan

AU - Buchmann, Kurt

PY - 2017

Y1 - 2017

N2 - Excretory/secretory (ES) compounds isolated from third-stage larvae of the anisakid nematode Contracaecum osculatum parasitizing liver of Baltic cod were investigated for effects on immune gene expression in a zebrafish LPS-induced inflammation model. ES products containing a series of proteins, of which some had enzymatic activity, were injected solely or with LPS. ES proteins alone induced up-regulation of a number of immune-related genes, but generally to a lower degree compared to LPS. When co-injected with LPS, the worm products exacerbated merely expression of five genes affecting Th1, Th2, Th17 and innate responses compared to the LPS-injected group. However, the level of overexpression decreased in an inverse dose-dependent manner. The immune regulating action of C. osculatum ES products is interpreted as an important evolutionary ability of larval parasites in the transport host which makes it less susceptible to host immune responses whereby the probability of reaching the final host is increased.

AB - Excretory/secretory (ES) compounds isolated from third-stage larvae of the anisakid nematode Contracaecum osculatum parasitizing liver of Baltic cod were investigated for effects on immune gene expression in a zebrafish LPS-induced inflammation model. ES products containing a series of proteins, of which some had enzymatic activity, were injected solely or with LPS. ES proteins alone induced up-regulation of a number of immune-related genes, but generally to a lower degree compared to LPS. When co-injected with LPS, the worm products exacerbated merely expression of five genes affecting Th1, Th2, Th17 and innate responses compared to the LPS-injected group. However, the level of overexpression decreased in an inverse dose-dependent manner. The immune regulating action of C. osculatum ES products is interpreted as an important evolutionary ability of larval parasites in the transport host which makes it less susceptible to host immune responses whereby the probability of reaching the final host is increased.

U2 - 10.1371/journal.pone.0181277

DO - 10.1371/journal.pone.0181277

M3 - Journal article

VL - 12

JO - P L o S One

JF - P L o S One

SN - 1932-6203

IS - 7

M1 - e0181277

ER -

ID: 182538199