Heavier smoking may lead to a relative increase in waist circumference: evidence for a causal relationship from a Mendelian randomisation meta-analysis. The CARTA consortium

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Heavier smoking may lead to a relative increase in waist circumference : evidence for a causal relationship from a Mendelian randomisation meta-analysis. The CARTA consortium. / Morris, Richard W; Taylor, Amy E; Fluharty, Meg E; Bjørngaard, Johan H; Åsvold, Bjørn Olav; Elvestad Gabrielsen, Maiken; Campbell, Archie; Marioni, Riccardo; Kumari, Meena; Korhonen, Tellervo; Männistö, Satu; Marques-Vidal, Pedro; Kaakinen, Marika; Cavadino, Alana; Postmus, Iris; Husemoen, Lise Lotte N; Skaaby, Tea; Ahluwalia, Tarun Veer Singh; Treur, Jorien L; Willemsen, Gonneke; Dale, Caroline; Wannamethee, S Goya; Lahti, Jari; Palotie, Aarno; Räikkönen, Katri; McConnachie, Alex; Padmanabhan, Sandosh; Wong, Andrew; Dalgård, Christine; Paternoster, Lavinia; Ben-Shlomo, Yoav; Tyrrell, Jessica; Horwood, John; Fergusson, David M; Kennedy, Martin A; Nohr, Ellen A; Christiansen, Lene; Kyvik, Kirsten Ohm; Kuh, Diana; Watt, Graham; Eriksson, Johan G; Whincup, Peter H; Vink, Jacqueline M; Boomsma, Dorret I; Davey Smith, George; Lawlor, Debbie; Linneberg, Allan; Ford, Ian; Jukema, J Wouter; Power, Chris; Hyppönen, Elina; Jarvelin, Marjo-Riitta; Preisig, Martin; Borodulin, Katja; Kaprio, Jaakko; Kivimaki, Mika; Smith, Blair H; Hayward, Caroline; Romundstad, Pål R; Sørensen, Thorkild I A; Munafò, Marcus R; Sattar, Naveed.

I: B M J Open, Bind 5, Nr. 8, e008808, 2015, s. 1-10.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Morris, RW, Taylor, AE, Fluharty, ME, Bjørngaard, JH, Åsvold, BO, Elvestad Gabrielsen, M, Campbell, A, Marioni, R, Kumari, M, Korhonen, T, Männistö, S, Marques-Vidal, P, Kaakinen, M, Cavadino, A, Postmus, I, Husemoen, LLN, Skaaby, T, Ahluwalia, TVS, Treur, JL, Willemsen, G, Dale, C, Wannamethee, SG, Lahti, J, Palotie, A, Räikkönen, K, McConnachie, A, Padmanabhan, S, Wong, A, Dalgård, C, Paternoster, L, Ben-Shlomo, Y, Tyrrell, J, Horwood, J, Fergusson, DM, Kennedy, MA, Nohr, EA, Christiansen, L, Kyvik, KO, Kuh, D, Watt, G, Eriksson, JG, Whincup, PH, Vink, JM, Boomsma, DI, Davey Smith, G, Lawlor, D, Linneberg, A, Ford, I, Jukema, JW, Power, C, Hyppönen, E, Jarvelin, M-R, Preisig, M, Borodulin, K, Kaprio, J, Kivimaki, M, Smith, BH, Hayward, C, Romundstad, PR, Sørensen, TIA, Munafò, MR & Sattar, N 2015, 'Heavier smoking may lead to a relative increase in waist circumference: evidence for a causal relationship from a Mendelian randomisation meta-analysis. The CARTA consortium', B M J Open, bind 5, nr. 8, e008808, s. 1-10. https://doi.org/10.1136/bmjopen-2015-008808

APA

Morris, R. W., Taylor, A. E., Fluharty, M. E., Bjørngaard, J. H., Åsvold, B. O., Elvestad Gabrielsen, M., ... Sattar, N. (2015). Heavier smoking may lead to a relative increase in waist circumference: evidence for a causal relationship from a Mendelian randomisation meta-analysis. The CARTA consortium. B M J Open, 5(8), 1-10. [e008808]. https://doi.org/10.1136/bmjopen-2015-008808

Vancouver

Morris RW, Taylor AE, Fluharty ME, Bjørngaard JH, Åsvold BO, Elvestad Gabrielsen M o.a. Heavier smoking may lead to a relative increase in waist circumference: evidence for a causal relationship from a Mendelian randomisation meta-analysis. The CARTA consortium. B M J Open. 2015;5(8):1-10. e008808. https://doi.org/10.1136/bmjopen-2015-008808

Author

Morris, Richard W ; Taylor, Amy E ; Fluharty, Meg E ; Bjørngaard, Johan H ; Åsvold, Bjørn Olav ; Elvestad Gabrielsen, Maiken ; Campbell, Archie ; Marioni, Riccardo ; Kumari, Meena ; Korhonen, Tellervo ; Männistö, Satu ; Marques-Vidal, Pedro ; Kaakinen, Marika ; Cavadino, Alana ; Postmus, Iris ; Husemoen, Lise Lotte N ; Skaaby, Tea ; Ahluwalia, Tarun Veer Singh ; Treur, Jorien L ; Willemsen, Gonneke ; Dale, Caroline ; Wannamethee, S Goya ; Lahti, Jari ; Palotie, Aarno ; Räikkönen, Katri ; McConnachie, Alex ; Padmanabhan, Sandosh ; Wong, Andrew ; Dalgård, Christine ; Paternoster, Lavinia ; Ben-Shlomo, Yoav ; Tyrrell, Jessica ; Horwood, John ; Fergusson, David M ; Kennedy, Martin A ; Nohr, Ellen A ; Christiansen, Lene ; Kyvik, Kirsten Ohm ; Kuh, Diana ; Watt, Graham ; Eriksson, Johan G ; Whincup, Peter H ; Vink, Jacqueline M ; Boomsma, Dorret I ; Davey Smith, George ; Lawlor, Debbie ; Linneberg, Allan ; Ford, Ian ; Jukema, J Wouter ; Power, Chris ; Hyppönen, Elina ; Jarvelin, Marjo-Riitta ; Preisig, Martin ; Borodulin, Katja ; Kaprio, Jaakko ; Kivimaki, Mika ; Smith, Blair H ; Hayward, Caroline ; Romundstad, Pål R ; Sørensen, Thorkild I A ; Munafò, Marcus R ; Sattar, Naveed. / Heavier smoking may lead to a relative increase in waist circumference : evidence for a causal relationship from a Mendelian randomisation meta-analysis. The CARTA consortium. I: B M J Open. 2015 ; Bind 5, Nr. 8. s. 1-10.

Bibtex

@article{efd3739048034a098d010674f45b518a,
title = "Heavier smoking may lead to a relative increase in waist circumference: evidence for a causal relationship from a Mendelian randomisation meta-analysis. The CARTA consortium",
abstract = "OBJECTIVES: To investigate, using a Mendelian randomisation approach, whether heavier smoking is associated with a range of regional adiposity phenotypes, in particular those related to abdominal adiposity.DESIGN: Mendelian randomisation meta-analyses using a genetic variant (rs16969968/rs1051730 in the CHRNA5-CHRNA3-CHRNB4 gene region) as a proxy for smoking heaviness, of the associations of smoking heaviness with a range of adiposity phenotypes.PARTICIPANTS: 148,731 current, former and never-smokers of European ancestry aged ≥ 16 years from 29 studies in the consortium for Causal Analysis Research in Tobacco and Alcohol (CARTA).PRIMARY OUTCOME MEASURES: Waist and hip circumferences, and waist-hip ratio.RESULTS: The data included up to 66,809 never-smokers, 43,009 former smokers and 38,913 current daily cigarette smokers. Among current smokers, for each extra minor allele, the geometric mean was lower for waist circumference by -0.40{\%} (95{\%} CI -0.57{\%} to -0.22{\%}), with effects on hip circumference, waist-hip ratio and body mass index (BMI) being -0.31{\%} (95{\%} CI -0.42{\%} to -0.19), -0.08{\%} (-0.19{\%} to 0.03{\%}) and -0.74{\%} (-0.96{\%} to -0.51{\%}), respectively. In contrast, among never-smokers, these effects were higher by 0.23{\%} (0.09{\%} to 0.36{\%}), 0.17{\%} (0.08{\%} to 0.26{\%}), 0.07{\%} (-0.01{\%} to 0.15{\%}) and 0.35{\%} (0.18{\%} to 0.52{\%}), respectively. When adjusting the three central adiposity measures for BMI, the effects among current smokers changed direction and were higher by 0.14{\%} (0.05{\%} to 0.22{\%}) for waist circumference, 0.02{\%} (-0.05{\%} to 0.08{\%}) for hip circumference and 0.10{\%} (0.02{\%} to 0.19{\%}) for waist-hip ratio, for each extra minor allele.CONCLUSIONS: For a given BMI, a gene variant associated with increased cigarette consumption was associated with increased waist circumference. Smoking in an effort to control weight may lead to accumulation of central adiposity.",
author = "Morris, {Richard W} and Taylor, {Amy E} and Fluharty, {Meg E} and Bj{\o}rngaard, {Johan H} and {\AA}svold, {Bj{\o}rn Olav} and {Elvestad Gabrielsen}, Maiken and Archie Campbell and Riccardo Marioni and Meena Kumari and Tellervo Korhonen and Satu M{\"a}nnist{\"o} and Pedro Marques-Vidal and Marika Kaakinen and Alana Cavadino and Iris Postmus and Husemoen, {Lise Lotte N} and Tea Skaaby and Ahluwalia, {Tarun Veer Singh} and Treur, {Jorien L} and Gonneke Willemsen and Caroline Dale and Wannamethee, {S Goya} and Jari Lahti and Aarno Palotie and Katri R{\"a}ikk{\"o}nen and Alex McConnachie and Sandosh Padmanabhan and Andrew Wong and Christine Dalg{\aa}rd and Lavinia Paternoster and Yoav Ben-Shlomo and Jessica Tyrrell and John Horwood and Fergusson, {David M} and Kennedy, {Martin A} and Nohr, {Ellen A} and Lene Christiansen and Kyvik, {Kirsten Ohm} and Diana Kuh and Graham Watt and Eriksson, {Johan G} and Whincup, {Peter H} and Vink, {Jacqueline M} and Boomsma, {Dorret I} and {Davey Smith}, George and Debbie Lawlor and Allan Linneberg and Ian Ford and Jukema, {J Wouter} and Chris Power and Elina Hypp{\"o}nen and Marjo-Riitta Jarvelin and Martin Preisig and Katja Borodulin and Jaakko Kaprio and Mika Kivimaki and Smith, {Blair H} and Caroline Hayward and Romundstad, {P{\aa}l R} and S{\o}rensen, {Thorkild I A} and Munaf{\`o}, {Marcus R} and Naveed Sattar",
note = "Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.",
year = "2015",
doi = "10.1136/bmjopen-2015-008808",
language = "English",
volume = "5",
pages = "1--10",
journal = "B M J Open",
issn = "2044-6055",
publisher = "BMJ Publishing Group",
number = "8",

}

RIS

TY - JOUR

T1 - Heavier smoking may lead to a relative increase in waist circumference

T2 - B M J Open

AU - Morris, Richard W

AU - Taylor, Amy E

AU - Fluharty, Meg E

AU - Bjørngaard, Johan H

AU - Åsvold, Bjørn Olav

AU - Elvestad Gabrielsen, Maiken

AU - Campbell, Archie

AU - Marioni, Riccardo

AU - Kumari, Meena

AU - Korhonen, Tellervo

AU - Männistö, Satu

AU - Marques-Vidal, Pedro

AU - Kaakinen, Marika

AU - Cavadino, Alana

AU - Postmus, Iris

AU - Husemoen, Lise Lotte N

AU - Skaaby, Tea

AU - Ahluwalia, Tarun Veer Singh

AU - Treur, Jorien L

AU - Willemsen, Gonneke

AU - Dale, Caroline

AU - Wannamethee, S Goya

AU - Lahti, Jari

AU - Palotie, Aarno

AU - Räikkönen, Katri

AU - McConnachie, Alex

AU - Padmanabhan, Sandosh

AU - Wong, Andrew

AU - Dalgård, Christine

AU - Paternoster, Lavinia

AU - Ben-Shlomo, Yoav

AU - Tyrrell, Jessica

AU - Horwood, John

AU - Fergusson, David M

AU - Kennedy, Martin A

AU - Nohr, Ellen A

AU - Christiansen, Lene

AU - Kyvik, Kirsten Ohm

AU - Kuh, Diana

AU - Watt, Graham

AU - Eriksson, Johan G

AU - Whincup, Peter H

AU - Vink, Jacqueline M

AU - Boomsma, Dorret I

AU - Davey Smith, George

AU - Lawlor, Debbie

AU - Linneberg, Allan

AU - Ford, Ian

AU - Jukema, J Wouter

AU - Power, Chris

AU - Hyppönen, Elina

AU - Jarvelin, Marjo-Riitta

AU - Preisig, Martin

AU - Borodulin, Katja

AU - Kaprio, Jaakko

AU - Kivimaki, Mika

AU - Smith, Blair H

AU - Hayward, Caroline

AU - Romundstad, Pål R

AU - Sørensen, Thorkild I A

AU - Munafò, Marcus R

AU - Sattar, Naveed

N1 - Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

PY - 2015

Y1 - 2015

N2 - OBJECTIVES: To investigate, using a Mendelian randomisation approach, whether heavier smoking is associated with a range of regional adiposity phenotypes, in particular those related to abdominal adiposity.DESIGN: Mendelian randomisation meta-analyses using a genetic variant (rs16969968/rs1051730 in the CHRNA5-CHRNA3-CHRNB4 gene region) as a proxy for smoking heaviness, of the associations of smoking heaviness with a range of adiposity phenotypes.PARTICIPANTS: 148,731 current, former and never-smokers of European ancestry aged ≥ 16 years from 29 studies in the consortium for Causal Analysis Research in Tobacco and Alcohol (CARTA).PRIMARY OUTCOME MEASURES: Waist and hip circumferences, and waist-hip ratio.RESULTS: The data included up to 66,809 never-smokers, 43,009 former smokers and 38,913 current daily cigarette smokers. Among current smokers, for each extra minor allele, the geometric mean was lower for waist circumference by -0.40% (95% CI -0.57% to -0.22%), with effects on hip circumference, waist-hip ratio and body mass index (BMI) being -0.31% (95% CI -0.42% to -0.19), -0.08% (-0.19% to 0.03%) and -0.74% (-0.96% to -0.51%), respectively. In contrast, among never-smokers, these effects were higher by 0.23% (0.09% to 0.36%), 0.17% (0.08% to 0.26%), 0.07% (-0.01% to 0.15%) and 0.35% (0.18% to 0.52%), respectively. When adjusting the three central adiposity measures for BMI, the effects among current smokers changed direction and were higher by 0.14% (0.05% to 0.22%) for waist circumference, 0.02% (-0.05% to 0.08%) for hip circumference and 0.10% (0.02% to 0.19%) for waist-hip ratio, for each extra minor allele.CONCLUSIONS: For a given BMI, a gene variant associated with increased cigarette consumption was associated with increased waist circumference. Smoking in an effort to control weight may lead to accumulation of central adiposity.

AB - OBJECTIVES: To investigate, using a Mendelian randomisation approach, whether heavier smoking is associated with a range of regional adiposity phenotypes, in particular those related to abdominal adiposity.DESIGN: Mendelian randomisation meta-analyses using a genetic variant (rs16969968/rs1051730 in the CHRNA5-CHRNA3-CHRNB4 gene region) as a proxy for smoking heaviness, of the associations of smoking heaviness with a range of adiposity phenotypes.PARTICIPANTS: 148,731 current, former and never-smokers of European ancestry aged ≥ 16 years from 29 studies in the consortium for Causal Analysis Research in Tobacco and Alcohol (CARTA).PRIMARY OUTCOME MEASURES: Waist and hip circumferences, and waist-hip ratio.RESULTS: The data included up to 66,809 never-smokers, 43,009 former smokers and 38,913 current daily cigarette smokers. Among current smokers, for each extra minor allele, the geometric mean was lower for waist circumference by -0.40% (95% CI -0.57% to -0.22%), with effects on hip circumference, waist-hip ratio and body mass index (BMI) being -0.31% (95% CI -0.42% to -0.19), -0.08% (-0.19% to 0.03%) and -0.74% (-0.96% to -0.51%), respectively. In contrast, among never-smokers, these effects were higher by 0.23% (0.09% to 0.36%), 0.17% (0.08% to 0.26%), 0.07% (-0.01% to 0.15%) and 0.35% (0.18% to 0.52%), respectively. When adjusting the three central adiposity measures for BMI, the effects among current smokers changed direction and were higher by 0.14% (0.05% to 0.22%) for waist circumference, 0.02% (-0.05% to 0.08%) for hip circumference and 0.10% (0.02% to 0.19%) for waist-hip ratio, for each extra minor allele.CONCLUSIONS: For a given BMI, a gene variant associated with increased cigarette consumption was associated with increased waist circumference. Smoking in an effort to control weight may lead to accumulation of central adiposity.

U2 - 10.1136/bmjopen-2015-008808

DO - 10.1136/bmjopen-2015-008808

M3 - Journal article

VL - 5

SP - 1

EP - 10

JO - B M J Open

JF - B M J Open

SN - 2044-6055

IS - 8

M1 - e008808

ER -

ID: 150708484