Genetic profiles of gastroesophageal cancer: combined analysis using expression array and tiling array--comparative genomic hybridization

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Genetic profiles of gastroesophageal cancer: combined analysis using expression array and tiling array--comparative genomic hybridization. / Isinger-Ekstrand, Anna; Johansson, Jan; Ohlsson, Mattias; Francis, Princy; Staaf, Johan; Jönsson, Mats; Borg, Ake; Nilbert, Mef; Isinger-Ekstrand, Anna; Johansson, Jan; Ohlsson, Mattias; Francis, Princy; Staaf, Johan; Jönsson, Mats; Borg, Ake; Nilbert, Mef.

I: Cancer Genetics and Cytogenetics, Bind 200, Nr. 2, 2010, s. 120-6.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Isinger-Ekstrand, A, Johansson, J, Ohlsson, M, Francis, P, Staaf, J, Jönsson, M, Borg, A, Nilbert, M, Isinger-Ekstrand, A, Johansson, J, Ohlsson, M, Francis, P, Staaf, J, Jönsson, M, Borg, A & Nilbert, M 2010, 'Genetic profiles of gastroesophageal cancer: combined analysis using expression array and tiling array--comparative genomic hybridization' Cancer Genetics and Cytogenetics, bind 200, nr. 2, s. 120-6. https://doi.org/10.1016/j.cancergencyto.2010.03.013

APA

Isinger-Ekstrand, A., Johansson, J., Ohlsson, M., Francis, P., Staaf, J., Jönsson, M., ... Nilbert, M. (2010). Genetic profiles of gastroesophageal cancer: combined analysis using expression array and tiling array--comparative genomic hybridization. Cancer Genetics and Cytogenetics, 200(2), 120-6. https://doi.org/10.1016/j.cancergencyto.2010.03.013

Vancouver

Isinger-Ekstrand A, Johansson J, Ohlsson M, Francis P, Staaf J, Jönsson M o.a. Genetic profiles of gastroesophageal cancer: combined analysis using expression array and tiling array--comparative genomic hybridization. Cancer Genetics and Cytogenetics. 2010;200(2):120-6. https://doi.org/10.1016/j.cancergencyto.2010.03.013

Author

Isinger-Ekstrand, Anna ; Johansson, Jan ; Ohlsson, Mattias ; Francis, Princy ; Staaf, Johan ; Jönsson, Mats ; Borg, Ake ; Nilbert, Mef ; Isinger-Ekstrand, Anna ; Johansson, Jan ; Ohlsson, Mattias ; Francis, Princy ; Staaf, Johan ; Jönsson, Mats ; Borg, Ake ; Nilbert, Mef. / Genetic profiles of gastroesophageal cancer: combined analysis using expression array and tiling array--comparative genomic hybridization. I: Cancer Genetics and Cytogenetics. 2010 ; Bind 200, Nr. 2. s. 120-6.

Bibtex

@article{072e15066c6945e6af6d34bf9094875c,
title = "Genetic profiles of gastroesophageal cancer: combined analysis using expression array and tiling array--comparative genomic hybridization",
abstract = "We aimed to characterize the genomic profiles of adenocarcinomas in the gastroesophageal junction in relation to cancers in the esophagus and the stomach. Profiles of gains/losses as well as gene expression profiles were obtained from 27 gastroesophageal adenocarcinomas by means of 32k high-resolution array-based comparative genomic hybridization and 27k oligo gene expression arrays, and putative target genes were validated in an extended series. Adenocarcinomas in the distal esophagus and the gastroesophageal junction showed strong similarities with the most common gains at 20q13, 8q24, 1q21-23, 5p15, 13q34, and 12q13, whereas different profiles with gains at 5p15, 7p22, 2q35, and 13q34 characterized gastric cancers. CDK6 and EGFR were identified as putative target genes in cancers of the esophagus and the gastroesophageal junction, with upregulation in one quarter of the tumors. Gains/losses and gene expression profiles show strong similarity between cancers in the distal esophagus and the gastroesophageal junction with frequent upregulation of CDK6 and EGFR, whereas gastric cancer displays distinct genetic changes. These data suggest that molecular diagnostics and targeted therapies can be applied to adenocarcinomas of the distal esophagus and gastroesophageal junction alike.",
author = "Anna Isinger-Ekstrand and Jan Johansson and Mattias Ohlsson and Princy Francis and Johan Staaf and Mats J{\~A}¶nsson and Ake Borg and Mef Nilbert and Anna Isinger-Ekstrand and Jan Johansson and Mattias Ohlsson and Princy Francis and Johan Staaf and Mats J{\"o}nsson and Ake Borg and Mef Nilbert",
note = "Copyright (c) 2010 Elsevier Inc. All rights reserved.",
year = "2010",
doi = "http://dx.doi.org/10.1016/j.cancergencyto.2010.03.013",
language = "English",
volume = "200",
pages = "120--6",
journal = "Cancer genetics and cytogenetics",
issn = "0165-4608",
publisher = "Elsevier",
number = "2",

}

RIS

TY - JOUR

T1 - Genetic profiles of gastroesophageal cancer: combined analysis using expression array and tiling array--comparative genomic hybridization

AU - Isinger-Ekstrand, Anna

AU - Johansson, Jan

AU - Ohlsson, Mattias

AU - Francis, Princy

AU - Staaf, Johan

AU - Jönsson, Mats

AU - Borg, Ake

AU - Nilbert, Mef

AU - Isinger-Ekstrand, Anna

AU - Johansson, Jan

AU - Ohlsson, Mattias

AU - Francis, Princy

AU - Staaf, Johan

AU - Jönsson, Mats

AU - Borg, Ake

AU - Nilbert, Mef

N1 - Copyright (c) 2010 Elsevier Inc. All rights reserved.

PY - 2010

Y1 - 2010

N2 - We aimed to characterize the genomic profiles of adenocarcinomas in the gastroesophageal junction in relation to cancers in the esophagus and the stomach. Profiles of gains/losses as well as gene expression profiles were obtained from 27 gastroesophageal adenocarcinomas by means of 32k high-resolution array-based comparative genomic hybridization and 27k oligo gene expression arrays, and putative target genes were validated in an extended series. Adenocarcinomas in the distal esophagus and the gastroesophageal junction showed strong similarities with the most common gains at 20q13, 8q24, 1q21-23, 5p15, 13q34, and 12q13, whereas different profiles with gains at 5p15, 7p22, 2q35, and 13q34 characterized gastric cancers. CDK6 and EGFR were identified as putative target genes in cancers of the esophagus and the gastroesophageal junction, with upregulation in one quarter of the tumors. Gains/losses and gene expression profiles show strong similarity between cancers in the distal esophagus and the gastroesophageal junction with frequent upregulation of CDK6 and EGFR, whereas gastric cancer displays distinct genetic changes. These data suggest that molecular diagnostics and targeted therapies can be applied to adenocarcinomas of the distal esophagus and gastroesophageal junction alike.

AB - We aimed to characterize the genomic profiles of adenocarcinomas in the gastroesophageal junction in relation to cancers in the esophagus and the stomach. Profiles of gains/losses as well as gene expression profiles were obtained from 27 gastroesophageal adenocarcinomas by means of 32k high-resolution array-based comparative genomic hybridization and 27k oligo gene expression arrays, and putative target genes were validated in an extended series. Adenocarcinomas in the distal esophagus and the gastroesophageal junction showed strong similarities with the most common gains at 20q13, 8q24, 1q21-23, 5p15, 13q34, and 12q13, whereas different profiles with gains at 5p15, 7p22, 2q35, and 13q34 characterized gastric cancers. CDK6 and EGFR were identified as putative target genes in cancers of the esophagus and the gastroesophageal junction, with upregulation in one quarter of the tumors. Gains/losses and gene expression profiles show strong similarity between cancers in the distal esophagus and the gastroesophageal junction with frequent upregulation of CDK6 and EGFR, whereas gastric cancer displays distinct genetic changes. These data suggest that molecular diagnostics and targeted therapies can be applied to adenocarcinomas of the distal esophagus and gastroesophageal junction alike.

U2 - http://dx.doi.org/10.1016/j.cancergencyto.2010.03.013

DO - http://dx.doi.org/10.1016/j.cancergencyto.2010.03.013

M3 - Journal article

VL - 200

SP - 120

EP - 126

JO - Cancer genetics and cytogenetics

JF - Cancer genetics and cytogenetics

SN - 0165-4608

IS - 2

ER -

ID: 34374736