Generation of two iPSC lines with either a heterozygous V717I or a heterozygous KM670/671NL mutation in the APP gene

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Henriette R. Frederiksen, Bjørn Holst, Sarayu Ramakrishna, Ravi Muddashetty, Benjamin Schmid, Kristine Freude

Alzheimer's disease (AD) is the most common form of dementia, affecting millions of people worldwide. Mutations in the genes PSEN1, PSEN2 or APP are known to cause familial forms of AD with an early age of onset. In this study, specific pathogenic mutations in the APP gene were introduced into an iPSC line from a healthy individual by the use of CRISPR-Cas9. The study resulted in the generation of two new cell lines, one carrying the V717I APP mutation and one with the KM670/671NL APP mutation.

OriginalsprogEngelsk
Artikelnummer101368
TidsskriftStem Cell Research
Vol/bind34
Antal sider5
ISSN1873-5061
DOI
StatusUdgivet - 1 jan. 2019

Antal downloads er baseret på statistik fra Google Scholar og www.ku.dk


Ingen data tilgængelig

ID: 211945396