Exploring the Behavioral and Metabolic Phenotype Generated by Re-Introduction of the Ghrelin Receptor in the Ventral Tegmental Area

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Standard

Exploring the Behavioral and Metabolic Phenotype Generated by Re-Introduction of the Ghrelin Receptor in the Ventral Tegmental Area. / Skov, Louise J; Jensen, Morten; Christiansen, Søren H; Ratner, Cecilia; Woldbye, David P D; Holst, Birgitte.

I: International Journal of Molecular Sciences, Bind 18, Nr. 5, 914, 26.04.2017.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Skov, LJ, Jensen, M, Christiansen, SH, Ratner, C, Woldbye, DPD & Holst, B 2017, 'Exploring the Behavioral and Metabolic Phenotype Generated by Re-Introduction of the Ghrelin Receptor in the Ventral Tegmental Area', International Journal of Molecular Sciences, bind 18, nr. 5, 914. https://doi.org/10.3390/ijms18050914

APA

Skov, L. J., Jensen, M., Christiansen, S. H., Ratner, C., Woldbye, D. P. D., & Holst, B. (2017). Exploring the Behavioral and Metabolic Phenotype Generated by Re-Introduction of the Ghrelin Receptor in the Ventral Tegmental Area. International Journal of Molecular Sciences, 18(5), [914]. https://doi.org/10.3390/ijms18050914

Vancouver

Skov LJ, Jensen M, Christiansen SH, Ratner C, Woldbye DPD, Holst B. Exploring the Behavioral and Metabolic Phenotype Generated by Re-Introduction of the Ghrelin Receptor in the Ventral Tegmental Area. International Journal of Molecular Sciences. 2017 apr 26;18(5). 914. https://doi.org/10.3390/ijms18050914

Author

Skov, Louise J ; Jensen, Morten ; Christiansen, Søren H ; Ratner, Cecilia ; Woldbye, David P D ; Holst, Birgitte. / Exploring the Behavioral and Metabolic Phenotype Generated by Re-Introduction of the Ghrelin Receptor in the Ventral Tegmental Area. I: International Journal of Molecular Sciences. 2017 ; Bind 18, Nr. 5.

Bibtex

@article{6559952c5adc46e5879ffce236fde0d8,
title = "Exploring the Behavioral and Metabolic Phenotype Generated by Re-Introduction of the Ghrelin Receptor in the Ventral Tegmental Area",
abstract = "Ghrelin receptor (Ghr-R) signaling in neurons of the ventral tegmental area (VTA) can modulate dopaminergic function and the reward-related effects of both palatable foods and drugs of abuse. In this study, we re-introduced the Ghr-R in VTA neurons in Ghr-R knockout mice (Ghr-R(VTA) mice) to specifically study the importance of the constitutively active Ghr-R for VTA neuronal signaling. Our results showed that re-introduction of the Ghr-R in the VTA had no impact on body weight or food intake under basal conditions. However, during novel environment stress Ghr-R(VTA) mice showed increased food intake and energy expenditure compared to Ghr-R knockout mice, demonstrating the significance of Ghr-R signaling in the response to stress. Ghr-R(VTA) mice also showed increased cocaine-induced locomotor activity compared to Ghr-R knockout mice, highlighting the importance of ghrelin signaling for the reward-related effects of activation of VTA neurons. Overall, our data suggest that re-introduction of the Ghr-R in the mesolimbic reward system of Ghr-R knockout mice increases the level of activation induced by both cocaine and novelty stress.",
keywords = "Journal Article",
author = "Skov, {Louise J} and Morten Jensen and Christiansen, {S{\o}ren H} and Cecilia Ratner and Woldbye, {David P D} and Birgitte Holst",
year = "2017",
month = "4",
day = "26",
doi = "10.3390/ijms18050914",
language = "English",
volume = "18",
journal = "International Journal of Molecular Sciences (Online)",
issn = "1661-6596",
publisher = "MDPI AG",
number = "5",

}

RIS

TY - JOUR

T1 - Exploring the Behavioral and Metabolic Phenotype Generated by Re-Introduction of the Ghrelin Receptor in the Ventral Tegmental Area

AU - Skov, Louise J

AU - Jensen, Morten

AU - Christiansen, Søren H

AU - Ratner, Cecilia

AU - Woldbye, David P D

AU - Holst, Birgitte

PY - 2017/4/26

Y1 - 2017/4/26

N2 - Ghrelin receptor (Ghr-R) signaling in neurons of the ventral tegmental area (VTA) can modulate dopaminergic function and the reward-related effects of both palatable foods and drugs of abuse. In this study, we re-introduced the Ghr-R in VTA neurons in Ghr-R knockout mice (Ghr-R(VTA) mice) to specifically study the importance of the constitutively active Ghr-R for VTA neuronal signaling. Our results showed that re-introduction of the Ghr-R in the VTA had no impact on body weight or food intake under basal conditions. However, during novel environment stress Ghr-R(VTA) mice showed increased food intake and energy expenditure compared to Ghr-R knockout mice, demonstrating the significance of Ghr-R signaling in the response to stress. Ghr-R(VTA) mice also showed increased cocaine-induced locomotor activity compared to Ghr-R knockout mice, highlighting the importance of ghrelin signaling for the reward-related effects of activation of VTA neurons. Overall, our data suggest that re-introduction of the Ghr-R in the mesolimbic reward system of Ghr-R knockout mice increases the level of activation induced by both cocaine and novelty stress.

AB - Ghrelin receptor (Ghr-R) signaling in neurons of the ventral tegmental area (VTA) can modulate dopaminergic function and the reward-related effects of both palatable foods and drugs of abuse. In this study, we re-introduced the Ghr-R in VTA neurons in Ghr-R knockout mice (Ghr-R(VTA) mice) to specifically study the importance of the constitutively active Ghr-R for VTA neuronal signaling. Our results showed that re-introduction of the Ghr-R in the VTA had no impact on body weight or food intake under basal conditions. However, during novel environment stress Ghr-R(VTA) mice showed increased food intake and energy expenditure compared to Ghr-R knockout mice, demonstrating the significance of Ghr-R signaling in the response to stress. Ghr-R(VTA) mice also showed increased cocaine-induced locomotor activity compared to Ghr-R knockout mice, highlighting the importance of ghrelin signaling for the reward-related effects of activation of VTA neurons. Overall, our data suggest that re-introduction of the Ghr-R in the mesolimbic reward system of Ghr-R knockout mice increases the level of activation induced by both cocaine and novelty stress.

KW - Journal Article

U2 - 10.3390/ijms18050914

DO - 10.3390/ijms18050914

M3 - Journal article

VL - 18

JO - International Journal of Molecular Sciences (Online)

JF - International Journal of Molecular Sciences (Online)

SN - 1661-6596

IS - 5

M1 - 914

ER -

ID: 182972964