Effect of local hemostatics on bone induction in rats: a comparative study of bone wax, fibrin-collagen paste, and bioerodible polyorthoester with and without gentamicin

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Standard

Effect of local hemostatics on bone induction in rats: a comparative study of bone wax, fibrin-collagen paste, and bioerodible polyorthoester with and without gentamicin. / Solheim, E; Pinholt, E M; Bang, G; Sudmann, E.

I: Journal of Biomedical Materials Research, Bind 26, Nr. 6, 01.06.1992, s. 791-800.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Solheim, E, Pinholt, EM, Bang, G & Sudmann, E 1992, 'Effect of local hemostatics on bone induction in rats: a comparative study of bone wax, fibrin-collagen paste, and bioerodible polyorthoester with and without gentamicin' Journal of Biomedical Materials Research, bind 26, nr. 6, s. 791-800. https://doi.org/10.1002/jbm.820260608

APA

Solheim, E., Pinholt, E. M., Bang, G., & Sudmann, E. (1992). Effect of local hemostatics on bone induction in rats: a comparative study of bone wax, fibrin-collagen paste, and bioerodible polyorthoester with and without gentamicin. Journal of Biomedical Materials Research, 26(6), 791-800. https://doi.org/10.1002/jbm.820260608

Vancouver

Solheim E, Pinholt EM, Bang G, Sudmann E. Effect of local hemostatics on bone induction in rats: a comparative study of bone wax, fibrin-collagen paste, and bioerodible polyorthoester with and without gentamicin. Journal of Biomedical Materials Research. 1992 jun 1;26(6):791-800. https://doi.org/10.1002/jbm.820260608

Author

Solheim, E ; Pinholt, E M ; Bang, G ; Sudmann, E. / Effect of local hemostatics on bone induction in rats: a comparative study of bone wax, fibrin-collagen paste, and bioerodible polyorthoester with and without gentamicin. I: Journal of Biomedical Materials Research. 1992 ; Bind 26, Nr. 6. s. 791-800.

Bibtex

@article{cc8120cc247c4fdb9ee5ba8f4e0d292f,
title = "Effect of local hemostatics on bone induction in rats: a comparative study of bone wax, fibrin-collagen paste, and bioerodible polyorthoester with and without gentamicin",
abstract = "Local hemostatics for osseous tissue should preferably be absorbable and biocompatible and should not inhibit osteogenesis. The tissue response and effect on demineralized bone-induced heterotopic osteogenesis in the abdominal muscle of 120 male Wistar rats by different local hemostatics were evaluated by light microscopy and 85Sr uptake analyses. Non-absorbable bone wax of 88{\%} beeswax and absorbable bovine fibrin-collagen paste both significantly inhibited osteoinduction, whereas a bioerodible polyorthoester drug delivery system with or without 4{\%} gentamicin did not. Bone wax was not absorbed and induced a chronic foreign body reaction. Fibrin-collagen paste induced less inflammation with numerous monocytes and macrophages with engulfed material. Bioerodible polyorthoester caused a very moderate tissue reaction and was mostly resorbed at week 4.",
keywords = "Absorption, Animals, Biocompatible Materials, Bone and Bones, Collagen, Drug Combinations, Fibrin, Gentamicins, Hemostatics, Inflammation, Male, Materials Testing, Osteogenesis, Palmitates, Polyesters, Rats, Rats, Inbred Strains, Waxes",
author = "E Solheim and Pinholt, {E M} and G Bang and E Sudmann",
year = "1992",
month = "6",
day = "1",
doi = "10.1002/jbm.820260608",
language = "English",
volume = "26",
pages = "791--800",
journal = "Journal of Biomedical Materials Research",
issn = "0021-9304",
publisher = "John Wiley & Sons, Ltd",
number = "6",

}

RIS

TY - JOUR

T1 - Effect of local hemostatics on bone induction in rats: a comparative study of bone wax, fibrin-collagen paste, and bioerodible polyorthoester with and without gentamicin

AU - Solheim, E

AU - Pinholt, E M

AU - Bang, G

AU - Sudmann, E

PY - 1992/6/1

Y1 - 1992/6/1

N2 - Local hemostatics for osseous tissue should preferably be absorbable and biocompatible and should not inhibit osteogenesis. The tissue response and effect on demineralized bone-induced heterotopic osteogenesis in the abdominal muscle of 120 male Wistar rats by different local hemostatics were evaluated by light microscopy and 85Sr uptake analyses. Non-absorbable bone wax of 88% beeswax and absorbable bovine fibrin-collagen paste both significantly inhibited osteoinduction, whereas a bioerodible polyorthoester drug delivery system with or without 4% gentamicin did not. Bone wax was not absorbed and induced a chronic foreign body reaction. Fibrin-collagen paste induced less inflammation with numerous monocytes and macrophages with engulfed material. Bioerodible polyorthoester caused a very moderate tissue reaction and was mostly resorbed at week 4.

AB - Local hemostatics for osseous tissue should preferably be absorbable and biocompatible and should not inhibit osteogenesis. The tissue response and effect on demineralized bone-induced heterotopic osteogenesis in the abdominal muscle of 120 male Wistar rats by different local hemostatics were evaluated by light microscopy and 85Sr uptake analyses. Non-absorbable bone wax of 88% beeswax and absorbable bovine fibrin-collagen paste both significantly inhibited osteoinduction, whereas a bioerodible polyorthoester drug delivery system with or without 4% gentamicin did not. Bone wax was not absorbed and induced a chronic foreign body reaction. Fibrin-collagen paste induced less inflammation with numerous monocytes and macrophages with engulfed material. Bioerodible polyorthoester caused a very moderate tissue reaction and was mostly resorbed at week 4.

KW - Absorption

KW - Animals

KW - Biocompatible Materials

KW - Bone and Bones

KW - Collagen

KW - Drug Combinations

KW - Fibrin

KW - Gentamicins

KW - Hemostatics

KW - Inflammation

KW - Male

KW - Materials Testing

KW - Osteogenesis

KW - Palmitates

KW - Polyesters

KW - Rats

KW - Rats, Inbred Strains

KW - Waxes

U2 - 10.1002/jbm.820260608

DO - 10.1002/jbm.820260608

M3 - Journal article

VL - 26

SP - 791

EP - 800

JO - Journal of Biomedical Materials Research

JF - Journal of Biomedical Materials Research

SN - 0021-9304

IS - 6

ER -

ID: 33984782