Effect of administration of oral contraceptives on the synthesis and breakdown of myofibrillar proteins in young women

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M Hansen, Henning Langberg, L Holm, B F Miller, S G Petersen, S Doessing, D Skovgaard, T Trappe, M Kjaer

Oral contraceptive (OC) treatment has an inhibiting effect on protein synthesis in tendon and muscle connective tissue. We aimed to investigate whether OC influence myofibrillar protein turnover in young women. OC-users (24±2 years; Lindynette® n=7, Cilest® n=4) and non-OC-users (controls, 24±4 years n=12) performed one-legged kicking exercise. The next day, the myofibrillar protein fractional synthesis rate (FSR) was measured using stable isotopic tracers ((13)C-proline) while the subjects were fed standardized nutrient drinks. Simultaneously, a marker for myofibrillar protein breakdown, 3-methyl-histidine (3-MH), was measured in the interstitial fluid of the vastus lateralis. Measurements were performed in both legs. In general, myofibrillar protein FSR was lower in OC-users (two-way analysis of variance, P
OriginalsprogEngelsk
TidsskriftScandinavian Journal of Medicine & Science in Sports
Vol/bind21
Udgave nummer1
Sider (fra-til)62-72
Antal sider11
ISSN0905-7188
DOI
StatusUdgivet - 2011

ID: 38364393