Early Impact of Human Papillomavirus Vaccination on Cervical Neoplasia—Nationwide Follow-up of Young Danish Women

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Early Impact of Human Papillomavirus Vaccination on Cervical Neoplasia—Nationwide Follow-up of Young Danish Women. / Baldur-Felskov, Birgitte; Dehlendorff, Christian; Munk, Christian; Kjaer, Susanne K.

I: National Cancer Institute. Journal (Print), Bind 106, Nr. 3, djt460, 03.2014, s. 1-7.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Baldur-Felskov, B, Dehlendorff, C, Munk, C & Kjaer, SK 2014, 'Early Impact of Human Papillomavirus Vaccination on Cervical Neoplasia—Nationwide Follow-up of Young Danish Women', National Cancer Institute. Journal (Print), bind 106, nr. 3, djt460, s. 1-7. https://doi.org/10.1093/jnci/djt460

APA

Baldur-Felskov, B., Dehlendorff, C., Munk, C., & Kjaer, S. K. (2014). Early Impact of Human Papillomavirus Vaccination on Cervical Neoplasia—Nationwide Follow-up of Young Danish Women. National Cancer Institute. Journal (Print), 106(3), 1-7. [djt460]. https://doi.org/10.1093/jnci/djt460

Vancouver

Baldur-Felskov B, Dehlendorff C, Munk C, Kjaer SK. Early Impact of Human Papillomavirus Vaccination on Cervical Neoplasia—Nationwide Follow-up of Young Danish Women. National Cancer Institute. Journal (Print). 2014 mar;106(3):1-7. djt460. https://doi.org/10.1093/jnci/djt460

Author

Baldur-Felskov, Birgitte ; Dehlendorff, Christian ; Munk, Christian ; Kjaer, Susanne K. / Early Impact of Human Papillomavirus Vaccination on Cervical Neoplasia—Nationwide Follow-up of Young Danish Women. I: National Cancer Institute. Journal (Print). 2014 ; Bind 106, Nr. 3. s. 1-7.

Bibtex

@article{f91d39868f114ceab026e142bfbd03ba,
title = "Early Impact of Human Papillomavirus Vaccination on Cervical Neoplasia—Nationwide Follow-up of Young Danish Women",
abstract = "BACKGROUND: In clinical trials, vaccines against human papillomavirus (HPV) have been highly effective against HPV16- or HPV18-associated cervical lesions. The quadrivalent HPV vaccine was licensed in 2006 and subsequently implemented in the Danish vaccination program. The study aim was to use individual information on HPV vaccination status to assess subsequent risk of cervical lesions.METHODS: Using a cohort study design, we identified all girls and women born in Denmark in the period from 1989 to 1999 and obtained information on individual HPV vaccination status in the period from 2006 to 2012 from nationwide registries. Incident cases of cervical lesions were identified by linkage to the nationwide Pathology Data Bank. We compared vaccinated and unvaccinated girls and women stratified by birth cohort in Cox proportional hazards models.RESULTS: Risk of atypia or worse (atypia+) and of cervical intraepithelial neoplasia grade 2 or 3 (CIN2/3) were statistically significantly reduced among vaccinated women in birth cohorts 1991 to 1994 (1991-1992atypia+: hazard ratio [HR] = 0.46, two-sided 95{\%} confidence interval [CI] = 0.39 to 0.56; 1991-1992CIN2/3: HR = 0.56, 95{\%} CI = 0.37 to 0.84; 1993-1994atypia+: HR = 0.40, 95{\%} CI = 0.29 to 0.56; 1993-1994 CIN2/3: HR = 0.27, 95{\%} CI = 0.10 to 0.67). The birth cohort 1989 to 1990 had a statistically significantly reduced risk of atypia+ (HR = 0.75; 95{\%} CI = 0.65 to 0.86); the risk of CIN2/3 was also decreased but not statistically significant. No events occurred among girls in the birth cohort 1997 to 1999, whereas for the birth cohort 1995 to 1996 a hazard ratio could be calculated only for atypia+.CONCLUSIONS: Six years after licensure of the quadrivalent HPV vaccine in Denmark, a reduced risk of cervical lesions is observed at the population level.",
keywords = "Adolescent, Cervical Intraepithelial Neoplasia, Cohort Studies, Denmark, Female, Humans, Odds Ratio, Papillomavirus Infections, Papillomavirus Vaccines, Registries, Risk, Social Class, Uterine Cervical Neoplasms, Young Adult",
author = "Birgitte Baldur-Felskov and Christian Dehlendorff and Christian Munk and Kjaer, {Susanne K}",
year = "2014",
month = "3",
doi = "10.1093/jnci/djt460",
language = "English",
volume = "106",
pages = "1--7",
journal = "National Cancer Institute. Journal (Print)",
issn = "0027-8874",
publisher = "Oxford University Press",
number = "3",

}

RIS

TY - JOUR

T1 - Early Impact of Human Papillomavirus Vaccination on Cervical Neoplasia—Nationwide Follow-up of Young Danish Women

AU - Baldur-Felskov, Birgitte

AU - Dehlendorff, Christian

AU - Munk, Christian

AU - Kjaer, Susanne K

PY - 2014/3

Y1 - 2014/3

N2 - BACKGROUND: In clinical trials, vaccines against human papillomavirus (HPV) have been highly effective against HPV16- or HPV18-associated cervical lesions. The quadrivalent HPV vaccine was licensed in 2006 and subsequently implemented in the Danish vaccination program. The study aim was to use individual information on HPV vaccination status to assess subsequent risk of cervical lesions.METHODS: Using a cohort study design, we identified all girls and women born in Denmark in the period from 1989 to 1999 and obtained information on individual HPV vaccination status in the period from 2006 to 2012 from nationwide registries. Incident cases of cervical lesions were identified by linkage to the nationwide Pathology Data Bank. We compared vaccinated and unvaccinated girls and women stratified by birth cohort in Cox proportional hazards models.RESULTS: Risk of atypia or worse (atypia+) and of cervical intraepithelial neoplasia grade 2 or 3 (CIN2/3) were statistically significantly reduced among vaccinated women in birth cohorts 1991 to 1994 (1991-1992atypia+: hazard ratio [HR] = 0.46, two-sided 95% confidence interval [CI] = 0.39 to 0.56; 1991-1992CIN2/3: HR = 0.56, 95% CI = 0.37 to 0.84; 1993-1994atypia+: HR = 0.40, 95% CI = 0.29 to 0.56; 1993-1994 CIN2/3: HR = 0.27, 95% CI = 0.10 to 0.67). The birth cohort 1989 to 1990 had a statistically significantly reduced risk of atypia+ (HR = 0.75; 95% CI = 0.65 to 0.86); the risk of CIN2/3 was also decreased but not statistically significant. No events occurred among girls in the birth cohort 1997 to 1999, whereas for the birth cohort 1995 to 1996 a hazard ratio could be calculated only for atypia+.CONCLUSIONS: Six years after licensure of the quadrivalent HPV vaccine in Denmark, a reduced risk of cervical lesions is observed at the population level.

AB - BACKGROUND: In clinical trials, vaccines against human papillomavirus (HPV) have been highly effective against HPV16- or HPV18-associated cervical lesions. The quadrivalent HPV vaccine was licensed in 2006 and subsequently implemented in the Danish vaccination program. The study aim was to use individual information on HPV vaccination status to assess subsequent risk of cervical lesions.METHODS: Using a cohort study design, we identified all girls and women born in Denmark in the period from 1989 to 1999 and obtained information on individual HPV vaccination status in the period from 2006 to 2012 from nationwide registries. Incident cases of cervical lesions were identified by linkage to the nationwide Pathology Data Bank. We compared vaccinated and unvaccinated girls and women stratified by birth cohort in Cox proportional hazards models.RESULTS: Risk of atypia or worse (atypia+) and of cervical intraepithelial neoplasia grade 2 or 3 (CIN2/3) were statistically significantly reduced among vaccinated women in birth cohorts 1991 to 1994 (1991-1992atypia+: hazard ratio [HR] = 0.46, two-sided 95% confidence interval [CI] = 0.39 to 0.56; 1991-1992CIN2/3: HR = 0.56, 95% CI = 0.37 to 0.84; 1993-1994atypia+: HR = 0.40, 95% CI = 0.29 to 0.56; 1993-1994 CIN2/3: HR = 0.27, 95% CI = 0.10 to 0.67). The birth cohort 1989 to 1990 had a statistically significantly reduced risk of atypia+ (HR = 0.75; 95% CI = 0.65 to 0.86); the risk of CIN2/3 was also decreased but not statistically significant. No events occurred among girls in the birth cohort 1997 to 1999, whereas for the birth cohort 1995 to 1996 a hazard ratio could be calculated only for atypia+.CONCLUSIONS: Six years after licensure of the quadrivalent HPV vaccine in Denmark, a reduced risk of cervical lesions is observed at the population level.

KW - Adolescent

KW - Cervical Intraepithelial Neoplasia

KW - Cohort Studies

KW - Denmark

KW - Female

KW - Humans

KW - Odds Ratio

KW - Papillomavirus Infections

KW - Papillomavirus Vaccines

KW - Registries

KW - Risk

KW - Social Class

KW - Uterine Cervical Neoplasms

KW - Young Adult

U2 - 10.1093/jnci/djt460

DO - 10.1093/jnci/djt460

M3 - Journal article

VL - 106

SP - 1

EP - 7

JO - National Cancer Institute. Journal (Print)

T2 - National Cancer Institute. Journal (Print)

JF - National Cancer Institute. Journal (Print)

SN - 0027-8874

IS - 3

M1 - djt460

ER -

ID: 138416491