Concise synthesis of new bridged-nicotine analogues

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

François Crestey, Geert Hooyberghs, Jesper Langgaard Kristensen

This study describes a very efficient strategy for the synthesis of two new bridged-nicotine analogues. Starting from either 4- or 3-chloropyridine the desired tricyclic ring systems are accessed in just three steps in 23% and 40% overall yield, respectively.
OriginalsprogEngelsk
TidsskriftTetrahedron
Vol/bind68
Udgave nummer5
Sider (fra-til)1417-1421
ISSN0040-4020
DOI
StatusUdgivet - 4 feb. 2012

Bibliografisk note

Keywords: Pyridine metallation; Bridged-nicotine analogue; Suzukie-Miyaura cross-coupling reaction; Nicotinic acetylcholine receptor; Intramolecular reductive amination

ID: 37426122