Circulating Glucagon 1-61 Regulates Blood Glucose by Increasing Insulin Secretion and Hepatic Glucose Production

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Circulating Glucagon 1-61 Regulates Blood Glucose by Increasing Insulin Secretion and Hepatic Glucose Production. / Albrechtsen, Nicolai J. Wewer; Kuhre, Rune E.; Hornburg, Daniel; Jensen, Christian Z.; Hornum, Mads; Dirksen, Carsten; Svane, Maria; Gasbjerg, Laerke S.; Jorgensen, Nils B.; Gabe, Maria N.; Balk-Moller, Emilie; Albrechtsen, Reidar; Winther-Sorensen, Marie; Galsgaard, Katrine D.; Meissner, Felix; Jorsal, Tina; Lund, Asger; Vilsboll, Tina; Eliasen, Rasmus; Bojsen-Moller, Kirstine N.; Idorn, Thomas; Deacon, Carolyn F.; Knop, Filip K.; Rosenkilde, Mette M.; Hartmann, Bolette; Feldt-Rasmussen, Bo; Mann, Matthias; Madsbad, Sten; Holst, Jens J.

I: Cell Reports, Bind 21, Nr. 6, 11.2017, s. 1452-1460.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Albrechtsen, NJW, Kuhre, RE, Hornburg, D, Jensen, CZ, Hornum, M, Dirksen, C, Svane, M, Gasbjerg, LS, Jorgensen, NB, Gabe, MN, Balk-Moller, E, Albrechtsen, R, Winther-Sorensen, M, Galsgaard, KD, Meissner, F, Jorsal, T, Lund, A, Vilsboll, T, Eliasen, R, Bojsen-Moller, KN, Idorn, T, Deacon, CF, Knop, FK, Rosenkilde, MM, Hartmann, B, Feldt-Rasmussen, B, Mann, M, Madsbad, S & Holst, JJ 2017, 'Circulating Glucagon 1-61 Regulates Blood Glucose by Increasing Insulin Secretion and Hepatic Glucose Production', Cell Reports, bind 21, nr. 6, s. 1452-1460. https://doi.org/10.1016/j.celrep.2017.10.034

APA

Albrechtsen, N. J. W., Kuhre, R. E., Hornburg, D., Jensen, C. Z., Hornum, M., Dirksen, C., ... Holst, J. J. (2017). Circulating Glucagon 1-61 Regulates Blood Glucose by Increasing Insulin Secretion and Hepatic Glucose Production. Cell Reports, 21(6), 1452-1460. https://doi.org/10.1016/j.celrep.2017.10.034

Vancouver

Albrechtsen NJW, Kuhre RE, Hornburg D, Jensen CZ, Hornum M, Dirksen C o.a. Circulating Glucagon 1-61 Regulates Blood Glucose by Increasing Insulin Secretion and Hepatic Glucose Production. Cell Reports. 2017 nov;21(6):1452-1460. https://doi.org/10.1016/j.celrep.2017.10.034

Author

Albrechtsen, Nicolai J. Wewer ; Kuhre, Rune E. ; Hornburg, Daniel ; Jensen, Christian Z. ; Hornum, Mads ; Dirksen, Carsten ; Svane, Maria ; Gasbjerg, Laerke S. ; Jorgensen, Nils B. ; Gabe, Maria N. ; Balk-Moller, Emilie ; Albrechtsen, Reidar ; Winther-Sorensen, Marie ; Galsgaard, Katrine D. ; Meissner, Felix ; Jorsal, Tina ; Lund, Asger ; Vilsboll, Tina ; Eliasen, Rasmus ; Bojsen-Moller, Kirstine N. ; Idorn, Thomas ; Deacon, Carolyn F. ; Knop, Filip K. ; Rosenkilde, Mette M. ; Hartmann, Bolette ; Feldt-Rasmussen, Bo ; Mann, Matthias ; Madsbad, Sten ; Holst, Jens J. / Circulating Glucagon 1-61 Regulates Blood Glucose by Increasing Insulin Secretion and Hepatic Glucose Production. I: Cell Reports. 2017 ; Bind 21, Nr. 6. s. 1452-1460.

Bibtex

@article{5de0f9aa7d954884a4861ef985f758da,
title = "Circulating Glucagon 1-61 Regulates Blood Glucose by Increasing Insulin Secretion and Hepatic Glucose Production",
abstract = "Glucagon is secreted from pancreatic α cells, and hypersecretion (hyperglucagonemia) contributes to diabetic hyperglycemia. Molecular heterogeneity in hyperglucagonemia is poorly investigated. By screening human plasma using high-resolution-proteomics, we identified several glucagon variants, among which proglucagon 1-61 (PG 1-61) appears to be the most abundant form. PG 1-61 is secreted in subjects with obesity, both before and after gastric bypass surgery, with protein and fat as the main drivers for secretion before surgery, but glucose after. Studies in hepatocytes and in β cells demonstrated that PG 1-61 dose-dependently increases levels of cAMP, through the glucagon receptor, and increases insulin secretion and protein levels of enzymes regulating glycogenolysis and gluconeogenesis. In rats, PG 1-61 increases blood glucose and plasma insulin and decreases plasma levels of amino acids in vivo. We conclude that glucagon variants, such as PG 1-61, may contribute to glucose regulation by stimulating hepatic glucose production and insulin secretion.",
author = "Albrechtsen, {Nicolai J. Wewer} and Kuhre, {Rune E.} and Daniel Hornburg and Jensen, {Christian Z.} and Mads Hornum and Carsten Dirksen and Maria Svane and Gasbjerg, {Laerke S.} and Jorgensen, {Nils B.} and Gabe, {Maria N.} and Emilie Balk-Moller and Reidar Albrechtsen and Marie Winther-Sorensen and Galsgaard, {Katrine D.} and Felix Meissner and Tina Jorsal and Asger Lund and Tina Vilsboll and Rasmus Eliasen and Bojsen-Moller, {Kirstine N.} and Thomas Idorn and Deacon, {Carolyn F.} and Knop, {Filip K.} and Rosenkilde, {Mette M.} and Bolette Hartmann and Bo Feldt-Rasmussen and Matthias Mann and Sten Madsbad and Holst, {Jens J.}",
year = "2017",
month = "11",
doi = "10.1016/j.celrep.2017.10.034",
language = "English",
volume = "21",
pages = "1452--1460",
journal = "Cell Reports",
issn = "2211-1247",
publisher = "Cell Press",
number = "6",

}

RIS

TY - JOUR

T1 - Circulating Glucagon 1-61 Regulates Blood Glucose by Increasing Insulin Secretion and Hepatic Glucose Production

AU - Albrechtsen, Nicolai J. Wewer

AU - Kuhre, Rune E.

AU - Hornburg, Daniel

AU - Jensen, Christian Z.

AU - Hornum, Mads

AU - Dirksen, Carsten

AU - Svane, Maria

AU - Gasbjerg, Laerke S.

AU - Jorgensen, Nils B.

AU - Gabe, Maria N.

AU - Balk-Moller, Emilie

AU - Albrechtsen, Reidar

AU - Winther-Sorensen, Marie

AU - Galsgaard, Katrine D.

AU - Meissner, Felix

AU - Jorsal, Tina

AU - Lund, Asger

AU - Vilsboll, Tina

AU - Eliasen, Rasmus

AU - Bojsen-Moller, Kirstine N.

AU - Idorn, Thomas

AU - Deacon, Carolyn F.

AU - Knop, Filip K.

AU - Rosenkilde, Mette M.

AU - Hartmann, Bolette

AU - Feldt-Rasmussen, Bo

AU - Mann, Matthias

AU - Madsbad, Sten

AU - Holst, Jens J.

PY - 2017/11

Y1 - 2017/11

N2 - Glucagon is secreted from pancreatic α cells, and hypersecretion (hyperglucagonemia) contributes to diabetic hyperglycemia. Molecular heterogeneity in hyperglucagonemia is poorly investigated. By screening human plasma using high-resolution-proteomics, we identified several glucagon variants, among which proglucagon 1-61 (PG 1-61) appears to be the most abundant form. PG 1-61 is secreted in subjects with obesity, both before and after gastric bypass surgery, with protein and fat as the main drivers for secretion before surgery, but glucose after. Studies in hepatocytes and in β cells demonstrated that PG 1-61 dose-dependently increases levels of cAMP, through the glucagon receptor, and increases insulin secretion and protein levels of enzymes regulating glycogenolysis and gluconeogenesis. In rats, PG 1-61 increases blood glucose and plasma insulin and decreases plasma levels of amino acids in vivo. We conclude that glucagon variants, such as PG 1-61, may contribute to glucose regulation by stimulating hepatic glucose production and insulin secretion.

AB - Glucagon is secreted from pancreatic α cells, and hypersecretion (hyperglucagonemia) contributes to diabetic hyperglycemia. Molecular heterogeneity in hyperglucagonemia is poorly investigated. By screening human plasma using high-resolution-proteomics, we identified several glucagon variants, among which proglucagon 1-61 (PG 1-61) appears to be the most abundant form. PG 1-61 is secreted in subjects with obesity, both before and after gastric bypass surgery, with protein and fat as the main drivers for secretion before surgery, but glucose after. Studies in hepatocytes and in β cells demonstrated that PG 1-61 dose-dependently increases levels of cAMP, through the glucagon receptor, and increases insulin secretion and protein levels of enzymes regulating glycogenolysis and gluconeogenesis. In rats, PG 1-61 increases blood glucose and plasma insulin and decreases plasma levels of amino acids in vivo. We conclude that glucagon variants, such as PG 1-61, may contribute to glucose regulation by stimulating hepatic glucose production and insulin secretion.

U2 - 10.1016/j.celrep.2017.10.034

DO - 10.1016/j.celrep.2017.10.034

M3 - Journal article

VL - 21

SP - 1452

EP - 1460

JO - Cell Reports

JF - Cell Reports

SN - 2211-1247

IS - 6

ER -

ID: 185994862