Blood lactate is an important energy source for the human brain

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Standard

Blood lactate is an important energy source for the human brain. / G., van Hall; Stromstad, M.; Rasmussen, P.; Jans, O.; Zaar, M.; Gam, Christiane Marie Bourgin; Quistorff, B.; Secher, Niels H.; Nielsen, H.B.

I: Journal of Cerebral Blood Flow and Metabolism, Bind 29, Nr. 6, 2009, s. 1121-9.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

G., VH, Stromstad, M, Rasmussen, P, Jans, O, Zaar, M, Gam, CMB, Quistorff, B, Secher, NH & Nielsen, HB 2009, 'Blood lactate is an important energy source for the human brain', Journal of Cerebral Blood Flow and Metabolism, bind 29, nr. 6, s. 1121-9. https://doi.org/10.1038/jcbfm.2009.35

APA

G., V. H., Stromstad, M., Rasmussen, P., Jans, O., Zaar, M., Gam, C. M. B., ... Nielsen, H. B. (2009). Blood lactate is an important energy source for the human brain. Journal of Cerebral Blood Flow and Metabolism, 29(6), 1121-9. https://doi.org/10.1038/jcbfm.2009.35

Vancouver

G. VH, Stromstad M, Rasmussen P, Jans O, Zaar M, Gam CMB o.a. Blood lactate is an important energy source for the human brain. Journal of Cerebral Blood Flow and Metabolism. 2009;29(6):1121-9. https://doi.org/10.1038/jcbfm.2009.35

Author

G., van Hall ; Stromstad, M. ; Rasmussen, P. ; Jans, O. ; Zaar, M. ; Gam, Christiane Marie Bourgin ; Quistorff, B. ; Secher, Niels H. ; Nielsen, H.B. / Blood lactate is an important energy source for the human brain. I: Journal of Cerebral Blood Flow and Metabolism. 2009 ; Bind 29, Nr. 6. s. 1121-9.

Bibtex

@article{8afbc9404f6d11de87b8000ea68e967b,
title = "Blood lactate is an important energy source for the human brain",
abstract = "Lactate is a potential energy source for the brain. The aim of this study was to establish whether systemic lactate is a brain energy source. We measured in vivo cerebral lactate kinetics and oxidation rates in 6 healthy individuals at rest with and without 90 mins of intravenous lactate infusion (36 mumol per kg bw per min), and during 30 mins of cycling exercise at 75{\%} of maximal oxygen uptake while the lactate infusion continued to establish arterial lactate concentrations of 0.89+/-0.08, 3.9+/-0.3, and 6.9+/-1.3 mmol/L, respectively. At rest, cerebral lactate utilization changed from a net lactate release of 0.06+/-0.01 to an uptake of 0.16+/-0.07 mmol/min during lactate infusion, with a concomitant decrease in the net glucose uptake. During exercise, the net cerebral lactate uptake was further increased to 0.28+/-0.16 mmol/min. Most (13)C-label from cerebral [1-(13)C]lactate uptake was released as (13)CO(2) with 100{\%}+/-24{\%}, 86{\%}+/-15{\%}, and 87{\%}+/-30{\%} at rest with and without lactate infusion and during exercise, respectively. The contribution of systemic lactate to cerebral energy expenditure was 8{\%}+/-2{\%}, 19{\%}+/-4{\%}, and 27{\%}+/-4{\%} for the respective conditions. In conclusion, systemic lactate is taken up and oxidized by the human brain and is an important substrate for the brain both under basal and hyperlactatemic conditions.Journal of Cerebral Blood Flow & Metabolism advance online publication, 1 April 2009; doi:10.1038/jcbfm.2009.35.",
author = "G., {van Hall} and M. Stromstad and P. Rasmussen and O. Jans and M. Zaar and Gam, {Christiane Marie Bourgin} and B. Quistorff and Secher, {Niels H.} and H.B. Nielsen",
year = "2009",
doi = "10.1038/jcbfm.2009.35",
language = "English",
volume = "29",
pages = "1121--9",
journal = "Journal of Cerebral Blood Flow and Metabolism",
issn = "0271-678X",
publisher = "SAGE Publications",
number = "6",

}

RIS

TY - JOUR

T1 - Blood lactate is an important energy source for the human brain

AU - G., van Hall

AU - Stromstad, M.

AU - Rasmussen, P.

AU - Jans, O.

AU - Zaar, M.

AU - Gam, Christiane Marie Bourgin

AU - Quistorff, B.

AU - Secher, Niels H.

AU - Nielsen, H.B.

PY - 2009

Y1 - 2009

N2 - Lactate is a potential energy source for the brain. The aim of this study was to establish whether systemic lactate is a brain energy source. We measured in vivo cerebral lactate kinetics and oxidation rates in 6 healthy individuals at rest with and without 90 mins of intravenous lactate infusion (36 mumol per kg bw per min), and during 30 mins of cycling exercise at 75% of maximal oxygen uptake while the lactate infusion continued to establish arterial lactate concentrations of 0.89+/-0.08, 3.9+/-0.3, and 6.9+/-1.3 mmol/L, respectively. At rest, cerebral lactate utilization changed from a net lactate release of 0.06+/-0.01 to an uptake of 0.16+/-0.07 mmol/min during lactate infusion, with a concomitant decrease in the net glucose uptake. During exercise, the net cerebral lactate uptake was further increased to 0.28+/-0.16 mmol/min. Most (13)C-label from cerebral [1-(13)C]lactate uptake was released as (13)CO(2) with 100%+/-24%, 86%+/-15%, and 87%+/-30% at rest with and without lactate infusion and during exercise, respectively. The contribution of systemic lactate to cerebral energy expenditure was 8%+/-2%, 19%+/-4%, and 27%+/-4% for the respective conditions. In conclusion, systemic lactate is taken up and oxidized by the human brain and is an important substrate for the brain both under basal and hyperlactatemic conditions.Journal of Cerebral Blood Flow & Metabolism advance online publication, 1 April 2009; doi:10.1038/jcbfm.2009.35.

AB - Lactate is a potential energy source for the brain. The aim of this study was to establish whether systemic lactate is a brain energy source. We measured in vivo cerebral lactate kinetics and oxidation rates in 6 healthy individuals at rest with and without 90 mins of intravenous lactate infusion (36 mumol per kg bw per min), and during 30 mins of cycling exercise at 75% of maximal oxygen uptake while the lactate infusion continued to establish arterial lactate concentrations of 0.89+/-0.08, 3.9+/-0.3, and 6.9+/-1.3 mmol/L, respectively. At rest, cerebral lactate utilization changed from a net lactate release of 0.06+/-0.01 to an uptake of 0.16+/-0.07 mmol/min during lactate infusion, with a concomitant decrease in the net glucose uptake. During exercise, the net cerebral lactate uptake was further increased to 0.28+/-0.16 mmol/min. Most (13)C-label from cerebral [1-(13)C]lactate uptake was released as (13)CO(2) with 100%+/-24%, 86%+/-15%, and 87%+/-30% at rest with and without lactate infusion and during exercise, respectively. The contribution of systemic lactate to cerebral energy expenditure was 8%+/-2%, 19%+/-4%, and 27%+/-4% for the respective conditions. In conclusion, systemic lactate is taken up and oxidized by the human brain and is an important substrate for the brain both under basal and hyperlactatemic conditions.Journal of Cerebral Blood Flow & Metabolism advance online publication, 1 April 2009; doi:10.1038/jcbfm.2009.35.

U2 - 10.1038/jcbfm.2009.35

DO - 10.1038/jcbfm.2009.35

M3 - Journal article

VL - 29

SP - 1121

EP - 1129

JO - Journal of Cerebral Blood Flow and Metabolism

T2 - Journal of Cerebral Blood Flow and Metabolism

JF - Journal of Cerebral Blood Flow and Metabolism

SN - 0271-678X

IS - 6

ER -

ID: 12484064