Beneficial effects of low alcohol exposure, but adverse effects of high alcohol intake on glymphatic function

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Standard

Beneficial effects of low alcohol exposure, but adverse effects of high alcohol intake on glymphatic function. / Lundgaard, Iben; Wang, Wei; Eberhardt, Allison; Vinitsky, Hanna Sophia; Reeves, Benjamin Cameron; Peng, Sisi; Lou, Nanhong; Hussain, Rashad; Nedergaard, Maiken.

I: Scientific Reports, Bind 8, Nr. 1, 2246, 2018.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Lundgaard, I, Wang, W, Eberhardt, A, Vinitsky, HS, Reeves, BC, Peng, S, Lou, N, Hussain, R & Nedergaard, M 2018, 'Beneficial effects of low alcohol exposure, but adverse effects of high alcohol intake on glymphatic function', Scientific Reports, bind 8, nr. 1, 2246. https://doi.org/10.1038/s41598-018-20424-y

APA

Lundgaard, I., Wang, W., Eberhardt, A., Vinitsky, H. S., Reeves, B. C., Peng, S., ... Nedergaard, M. (2018). Beneficial effects of low alcohol exposure, but adverse effects of high alcohol intake on glymphatic function. Scientific Reports, 8(1), [2246]. https://doi.org/10.1038/s41598-018-20424-y

Vancouver

Lundgaard I, Wang W, Eberhardt A, Vinitsky HS, Reeves BC, Peng S o.a. Beneficial effects of low alcohol exposure, but adverse effects of high alcohol intake on glymphatic function. Scientific Reports. 2018;8(1). 2246. https://doi.org/10.1038/s41598-018-20424-y

Author

Lundgaard, Iben ; Wang, Wei ; Eberhardt, Allison ; Vinitsky, Hanna Sophia ; Reeves, Benjamin Cameron ; Peng, Sisi ; Lou, Nanhong ; Hussain, Rashad ; Nedergaard, Maiken. / Beneficial effects of low alcohol exposure, but adverse effects of high alcohol intake on glymphatic function. I: Scientific Reports. 2018 ; Bind 8, Nr. 1.

Bibtex

@article{5adf81a3e0d344ac83bf395104ea46ea,
title = "Beneficial effects of low alcohol exposure, but adverse effects of high alcohol intake on glymphatic function",
abstract = "Prolonged intake of excessive amounts of ethanol is known to have adverse effects on the central nervous system (CNS). Here we investigated the effects of acute and chronic ethanol exposure and withdrawal from chronic ethanol exposure on glymphatic function, which is a brain-wide metabolite clearance system connected to the peripheral lymphatic system. Acute and chronic exposure to 1.5 g/kg (binge level) ethanol dramatically suppressed glymphatic function in awake mice. Chronic exposure to 1.5 g/kg ethanol increased GFAP expression and induced mislocation of the astrocyte-specific water channel aquaporin 4 (AQP4), but decreased the levels of several cytokines. Surprisingly, glymphatic function increased in mice treated with 0.5 g/kg (low dose) ethanol following acute exposure, as well as after one month of chronic exposure. Low doses of chronic ethanol intake were associated with a significant decrease in GFAP expression, with little change in the cytokine profile compared with the saline group. These observations suggest that ethanol has a J-shaped effect on the glymphatic system whereby low doses of ethanol increase glymphatic function. Conversely, chronic 1.5 g/kg ethanol intake induced reactive gliosis and perturbed glymphatic function, which possibly may contribute to the higher risk of dementia observed in heavy drinkers.",
author = "Iben Lundgaard and Wei Wang and Allison Eberhardt and Vinitsky, {Hanna Sophia} and Reeves, {Benjamin Cameron} and Sisi Peng and Nanhong Lou and Rashad Hussain and Maiken Nedergaard",
year = "2018",
doi = "10.1038/s41598-018-20424-y",
language = "English",
volume = "8",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "nature publishing group",
number = "1",

}

RIS

TY - JOUR

T1 - Beneficial effects of low alcohol exposure, but adverse effects of high alcohol intake on glymphatic function

AU - Lundgaard, Iben

AU - Wang, Wei

AU - Eberhardt, Allison

AU - Vinitsky, Hanna Sophia

AU - Reeves, Benjamin Cameron

AU - Peng, Sisi

AU - Lou, Nanhong

AU - Hussain, Rashad

AU - Nedergaard, Maiken

PY - 2018

Y1 - 2018

N2 - Prolonged intake of excessive amounts of ethanol is known to have adverse effects on the central nervous system (CNS). Here we investigated the effects of acute and chronic ethanol exposure and withdrawal from chronic ethanol exposure on glymphatic function, which is a brain-wide metabolite clearance system connected to the peripheral lymphatic system. Acute and chronic exposure to 1.5 g/kg (binge level) ethanol dramatically suppressed glymphatic function in awake mice. Chronic exposure to 1.5 g/kg ethanol increased GFAP expression and induced mislocation of the astrocyte-specific water channel aquaporin 4 (AQP4), but decreased the levels of several cytokines. Surprisingly, glymphatic function increased in mice treated with 0.5 g/kg (low dose) ethanol following acute exposure, as well as after one month of chronic exposure. Low doses of chronic ethanol intake were associated with a significant decrease in GFAP expression, with little change in the cytokine profile compared with the saline group. These observations suggest that ethanol has a J-shaped effect on the glymphatic system whereby low doses of ethanol increase glymphatic function. Conversely, chronic 1.5 g/kg ethanol intake induced reactive gliosis and perturbed glymphatic function, which possibly may contribute to the higher risk of dementia observed in heavy drinkers.

AB - Prolonged intake of excessive amounts of ethanol is known to have adverse effects on the central nervous system (CNS). Here we investigated the effects of acute and chronic ethanol exposure and withdrawal from chronic ethanol exposure on glymphatic function, which is a brain-wide metabolite clearance system connected to the peripheral lymphatic system. Acute and chronic exposure to 1.5 g/kg (binge level) ethanol dramatically suppressed glymphatic function in awake mice. Chronic exposure to 1.5 g/kg ethanol increased GFAP expression and induced mislocation of the astrocyte-specific water channel aquaporin 4 (AQP4), but decreased the levels of several cytokines. Surprisingly, glymphatic function increased in mice treated with 0.5 g/kg (low dose) ethanol following acute exposure, as well as after one month of chronic exposure. Low doses of chronic ethanol intake were associated with a significant decrease in GFAP expression, with little change in the cytokine profile compared with the saline group. These observations suggest that ethanol has a J-shaped effect on the glymphatic system whereby low doses of ethanol increase glymphatic function. Conversely, chronic 1.5 g/kg ethanol intake induced reactive gliosis and perturbed glymphatic function, which possibly may contribute to the higher risk of dementia observed in heavy drinkers.

U2 - 10.1038/s41598-018-20424-y

DO - 10.1038/s41598-018-20424-y

M3 - Journal article

VL - 8

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

IS - 1

M1 - 2246

ER -

ID: 203407309