Bacterial membrane activity of alpha-peptide/beta-peptoid chimeras: influence of amino acid composition and chain length on the activity against different bacterial strains

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Line Hein-Kristensen, Kolja Michael Knapp, Henrik Franzyk, Lone Gram

Characterization and use of antimicrobial peptides (AMPs) requires that their mode of action is determined. The interaction of membrane-active peptides with their target is often established using model membranes, however, the actual permeabilization of live bacterial cells and subsequent killing is usually not tested. In this report, six a-peptide/ß-peptoid chimeras were examined for the effect of amino acid/peptoid substitutions and chain length on the membrane perturbation and subsequent killing of food-borne and clinical bacterial isolates.
OriginalsprogEngelsk
TidsskriftB M C Microbiology
Vol/bind11
Udgave nummer1
Sider (fra-til)144
ISSN1471-2180
DOI
StatusUdgivet - 22 jun. 2011

ID: 35102412